黄芩素 T2858
品牌 | 厂商性质 | 产地 | 货期 |
---|---|---|---|
TargetMol | 生产商 | 美国 | 现货 |
性能特点
生化试剂,可用于动物细胞实验
规格 | CAS号 | 价格 | 操作 |
---|---|---|---|
1 mL | 491-67-8 | ¥385.00 | 询底价 |
100 mg | 491-67-8 | ¥418.00 | 询底价 |
500 mg | 491-67-8 | ¥997.00 | 询底价 |
50 mg | 491-67-8 | ¥253.00 | 询底价 |
Product Introduction
Bioactivity
英文名: Baicalein
描述: Baicalein (5,6,7-Trihydroxyflavone) 是一种黄嘌呤氧化酶抑制剂,其IC50值为 3.12 μM。
细胞实验: MTT assay is conducted to evaluate the effect of baicalein on proliferation of breast cancer cells. MDA-MB-231 cells are routinely digested, collected, and then seeded in 96-well plates at a density of 8×103 cells/well. After incubation for 12-24 hours, cells are treated with 0, 20, 40, 60, 80, 100, and 120 μM baicalein according to their experimental grouping and then incubated at 37°C for 24, 48, and 72 hours[3].
体外活性: Baicalein suppresses mitogen-induced T cell proliferation and cytokine secretion in vitro. Pre-treatment with baicalein significantly suppresses Con A or anti-CD3/CD28 mAb-induced proliferation and cytokine secretion at 25 μM. Baicalein treatment induces DNA binding of NF-κB while inhibiting thioredoxin activity in the nuclear compartment[2]. Baicalein suppresses the proliferation, migration, and invasion of MDA-MB-231 cells in a time- and dose-dependent manner. Baicalein significantly decreases the expression of SATB1 in MDA-MB-231 cells. Baicalein also downregulates the expression of Wnt1 and β-catenin proteins and transcription level of Wnt/β-catenin-targeted genes[3].
体内活性: Baicalein suppresses induction of graft versus host disease while not inhibiting the homeostatic proliferation of T-cells in mice. This observation clearly shows potent anti-inflammatory activity of baicalein in vivo[2]. Rats treated with baicalein are protected against an increase in heart to body weight ratio, plasma level of brain natriuretic peptides, intraventricular septum thickness, myocardial collagen volume of left ventricle (all P<0.05, respectively). The antifibrotic effects of baicalein are further illustrated by the suppressed expression of left ventricle pro-collagens I and III accompanied by the decreased expression of 12-lipoxygenase, and by reduced expression and activity of matrix metallopeptidase 9 and extracellular signal-regulated kinases. Baicalein can inhibit cardiac fibrosis in hypertensive rats[4].
存储条件: Powder: -20°C for 3 years | In solvent: -80°C for 1 year
溶解度: DMSO : 50 mg/mL (185.02 mM)
关键字: Inhibitor | Influenza Virus | Xanthine Oxidase | Ferroptosis | Baicalein | inhibit
相关产品: Lapatinib | ML162 | Dopamine hydrochloride | Brusatol | DL-Glutamine | Curcumin | SRS16-86 | Sorafenib tosylate | Ferroptosis-IN-1 | Deferiprone
相关库: Drug Repurposing Compound Library | NF-κB Signaling Compound Library | Anti-Metabolism Disease Compound Library | Inhibitor Library | Anti-virus Traditional Chinese Medicine Monomer Library | Traditional Chinese Medicine Monomer Library | Apoptosis Compound Library | Anti-Fibrosis Compound Library | Cuproptosis Compound Library | Flavonoid Natural Product Library
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注:该产品未在中华人民共和国食品药品监督管理部门申请医疗器械注册和备案,不可用于临床诊断或治疗等相关用途