化合物Slingshot inhibitor D3 T28804

Product Introduction
Bioactivity


英文名: Slingshot inhibitor D3

描述: Slingshot inhibitor D3 (JHN76359) 是具有选择性、竞争性、可逆性的Slingshot 抑制剂。它对Slingshot 1和Slingshot 2具有相似的抑制活性。它对Slingshot 1 的IC50为 3 μM；对Slingshot 2 的Ki 为 3.9 μM。

体外活性: Slingshot 1 had?IC50?value of 3 μM and Slingshot 2 had?Ki value of 3.9 μM.?Slingshot inhibitor D3 has similar inhibitory activitieswith Slingshot 1 and Slingshot 2.

体内活性: Slingshot inhibitor D3 (5 μM; 45 minutes; PC12 cells;) significantly blocks NGF-induced dephosphorylation of cofilin at 15 and 30 minutes. Slingshot inhibitor D3 (5 μM; 45 minutes; PC12 cells) significantly decreases the NGF-induced cell migration, consistent with its inhibitory role in cofilin dephosphorylation. Slingshot inhibitor D3 (HEK293 cells) specifically blocks angiotensin II-induced cofilin dephosphorylation. Slingshot inhibitor D3 prevents cofilin dephosphroylation through inhibition of Slingshot.

存储条件: Powder: -20°C for 3 years | In solvent: -80°C for 1 year

溶解度: DMSO : 23.08 mg/mL (50 mM)


关键字: Inhibitor | competitive | PC12 | reversible | selective | Slingshot inhibitor D-3 | HEK293 | Slingshot inhibitor D3 | JHN 76359 | Slingshot inhibitor D 3 | JHN-76359 | potent | inhibit

相关库: Bioactive Compounds Library Max | Inhibitor Library | Bioactive Compound Library | Anti-Infection Compound Library

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注：该产品未在中华人民共和国食品药品监督管理部门申请医疗器械注册和备案，不可用于临床诊断或治疗等相关用途