葫芦巴碱 T2887

Product Introduction
Bioactivity


英文名: Trigonelline

描述: Trigonelline (Trigenolline) 是一种大量存在于咖啡中的生物碱，具有潜在抗糖尿病活性。它是Nrf2抑制剂，可阻断 Nrf2 依赖的蛋白酶体活性，从而增强胰腺癌细胞凋亡。

体外活性: Treatment of cells with Trigonelline attenuates H2O2 induced cell deaths and improves the antioxidant activity. In addition, Trigonelline regulates the apoptotic gene caspase-3, caspase-9, and anti-apoptotic gene Bcl-2, Bcl-XL during H2O2 induced oxidative stress in H9c2 cells. Trigonelline significantly reduces the H2O2 induced necrosis and apoptosis in H9c2 cells. However, the further increment of Trigonelline concentration against H2O2 can induce the necrosis and apoptosis along with H2O2[1].

体内活性: Trigonelline decreases bone mineralization and tends to worsen bone mechanical properties in streptozotocin-induced diabetic rats. Trigonelline significantly increases bone mineral density (BMD) and tends to improve cancellous bone strength in nicotinamide/streptozotocin-treated rats. Trigonelline differentially affects the skeletal system of rats with streptozotocin-induced metabolic disorders like intensify the osteoporotic changes in streptozotocin-treated rats and favorably affect bones in the non-hyperglycemic (nicotinamide/streptozotocin-treated) rats[2].

存储条件: keep away from direct sunlightPowder: -20°C for 3 years | In solvent: -80°C for 1 year

溶解度: H2O : Insoluble
DMSO : 10 mM
Ethanol : Insoluble


关键字: Inhibitor | Ferroptosis | Apoptosis | Trigonelline | Endogenous Metabolite | inhibit

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相关库: Anti-Inflammatory Traditional Chinese Medicine Compound Library | Marine Natural Product Library | Tobacco Monomer Library | Bioactive Compounds Library Max | Human Metabolite Library | Inhibitor Library | Traditional Chinese Medicine Monomer Library | Anti-Cancer Active Compound Library | Apoptosis Compound Library | Food as Medicine Compound Library

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注：该产品未在中华人民共和国食品药品监督管理部门申请医疗器械注册和备案，不可用于临床诊断或治疗等相关用途