化合物Tenofovir exalidex T28946
品牌 | 厂商性质 | 产地 | 货期 |
---|---|---|---|
TargetMol | 生产商 | 美国 | 现货 |
性能特点
生化试剂,可用于动物细胞实验
规格 | CAS号 | 价格 | 操作 |
---|---|---|---|
1 mg | 911208-73-6 | ¥283.00 | 询底价 |
10 mg | 911208-73-6 | ¥925.00 | 询底价 |
5 mg | 911208-73-6 | ¥668.00 | 询底价 |
25 mg | 911208-73-6 | ¥1,530.00 | 询底价 |
50 mg | 911208-73-6 | ¥2,650.00 | 询底价 |
100 mg | 911208-73-6 | ¥3,960.00 | 询底价 |
Product Introduction
Bioactivity
英文名: Tenofovir exalidex
描述: Tenofovir exalidex (CMX 157) 是一种非环核苷酸类似物 Tenofovir 的脂质结合物,对野生型和抗逆转录病毒耐药的 HIV 毒株,包括多药核苷/核苷酸类似物耐药病毒,都有活性。Tenofovir exalidex 对人外周血单个核细胞中所有主要的HIV-1和HIV-2亚型以及单核细胞来源的巨噬细胞中所有 HIV-1 菌株具有活性,EC50 范围在 0.2 和 7.2 nM 之间。Tenofovir exalidex 具有口服活性,无明显毒性。Tenofovir exalidex 对 HBV 也有活性。
体外活性: Tenofovir exalidex is consistently >300-fold more active than Tenofovir against multiple viruses in several different cell systems. Tenofovir exalidex will be effective against MNR mutants, including those that are unresponsive to all currently available NRTIs. Notably, the average EC50 in PBMCs for CMX157 against a panel of 27 wild-type HIV-1 isolates representing group M subtypes A to G and group O was 2.6 nM (range, 0.2 to 7.2 nM)[1]. Tenofovir exalidex exerts its therapeutic actions by inhibiting HBV polymerase-mediated HBV DNA elongation, but there is no known binding of cyclophilins to HBV polymerase nor participation of cyclophilins in DNA elongation. The combinational effect of CRV431 (host-targeting) and Tenofovir exalidex (direct-acting) on HBV DNA production is more consistent with the two compounds acting on distinct steps of the HBV life cycle[3].
体内活性: Tenofovir exalidex (Sprague-Dawley rats) is orally available and has no apparent toxicity when given orally to rats for 7 days at doses of 10, 30, or 100 mg/kg/day[2]. Tenofovir exalidex (5-10 mg/kg; oral gavage; daily for a period of 16 days) decreases liver HBV DNA levels dose-dependently[3].
存储条件: Powder: -20°C for 3 years | In solvent: -80°C for 1 year
溶解度: DMSO : Insoluble
关键字: Tenofovir exalidex
相关产品: BTA-188 | LCC-12 FA | Rociclovir | Pleconaril | 3-Oxobetulin | Brincidofovir | Edoxudine | 3’-O-Methyladenosine | Xibornol | Tizoxanide
相关库: Drug Repurposing Compound Library | Clinical Compound Library | Bioactive Compounds Library Max | Anti-Viral Compound Library | Bioactive Compound Library
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注:该产品未在中华人民共和国食品药品监督管理部门申请医疗器械注册和备案,不可用于临床诊断或治疗等相关用途