大豆苷 T2901

Product Introduction
Bioactivity


英文名: Daidzin

描述: Daidzin (Daidzoside) 是从大豆中分离出来的一种异黄酮，具有抗氧化、抗癌和抗动脉粥样硬化的活性。

细胞实验: CV-1 cells are transfected with 100 ng ERE-Luc and 50 ng ER-RARα or ER-RARγ. Transfected cells are treated with the indicated isoflavone at 0.5, 1, 10, 50, and 100 μM for 24 h. The β-Gal activity is used to normalize luciferase activity.  (Only for Reference)

体外活性: Daidzin, a glycoside of daidzein, increases the transcriptional activity of RARα and RARγ but does not bind to the RARs[1]. Daidzin does not inhibit human class Ⅰ, Ⅱ, or Ⅲ alcohol dehydrogenases, nor does it have any significant effect on biological systems that are known to be affected by other isoflavones. Daidzin inhibits human ALDH-I and ALDH-II in a concentration-dependent manner. Daidzin inhibits both ALDH-I and ALDH-II in an apparently competitive manner with Ki values of 40 nM and 20 μM, respectively, and it inhibits ALDH-I uncompetitively with respect to NAD+. The inhibition of ALDH-I by daidzin is reversible[3].

体内活性: Daidzin has no effect on alcohol-metabolizing enzymes(i.e., ADH and ALDH) when given to rats intragastrically. Chronic daidzin administration exerts an effect on alcohol pharmacokinetics, although the effect is less pronounced than when the compound is administered concurrently with ethanol.The compound is shown to shorten sleep time if ethanol is given intragastrically, but not when given intraperitoneally, indicating absence of effect on ethanol elimination rate. Daidzin delays ethanol absorption and lessens alcohol intoxication. The compound is shown to suppress the levels of BAC(blood alcohol concentration) for the first 3 hr after alcohol ingestion in both fasted and fed rats. These effects of daidzin may in part be due to its antioxidant activity[2].

存储条件: Powder: -20°C for 3 years | In solvent: -80°C for 1 year

溶解度: H2O : < 1 mg/mL (insoluble or slightly soluble)
DMSO : 50 mg/mL (120.09 mM)
Ethanol : 4 mg/mL (9.6 mM)


关键字: Inhibitor | inhibit | Mitochondrial Metabolism | Daidzin | Reverse Transcriptase

相关产品: Tiazofurin | DHODH-IN-15 | CVT-11127 | Tenuifoliside C | 11β-HSD1 inibitor 17 | LDCA | 2-Pyridinecarbohydrazide | AZD 4017 | DHODH-IN-14 | D-Mannitol

相关库: Drug Repurposing Compound Library | Anti-Cancer Drug Library | Chinese Pharmacopoeia Natural Product Library | Anti-Cancer Clinical Compound Library | Anti-Obesity Compound Library | Traditional Chinese Medicine Monomer Library | Anti-Cancer Approved Drug Library | Anti-Cancer Active Compound Library | Highly Selective Inhibitor Library | Tibetan medicine Compound Library

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