(E/Z)-虎杖苷 T2938

Product Introduction
Bioactivity


英文名: (E/Z)-Polydatin

描述: (E/Z)-Polydatin (Polydatin) 是从虎杖的根和根茎中分离得到的一种单晶化合物。它具有抗血小板聚集、心脏保护作用、抗低密度脂蛋白 (LDL) 氧化作用、抗炎和免疫调节功能。

体外活性: 在盲肠结扎穿孔诱导的败血症小鼠体内,Polydatin（15/45/100 mg/kg）可抑制CLP诱导的血清TNF-α和IL-6的产生、肺环氧合酶-2和诱导型NO合酶异构体的蛋白质表达及NF-κB活化,从而剂量依赖性降低败血症造成的死亡率和肺损伤.小鼠中Polydatin的LD50为1 g/kg（i.p.）.

体内活性: Polydatin是一种PLA2抑制剂,可使sPLA2-IIA mRNA表达和磷脂酶A2活性降低,还可使Clara细胞分泌蛋白的表达增加,从而减轻脂多糖诱导的肺部损伤。

存储条件: Powder: -20°C for 3 years | In solvent: -80°C for 1 year

溶解度: DMSO : 45 mg/mL (115.27 mM)
H2O : < 1 mg/mL (insoluble or slightly soluble)
Ethanol : < 1 mg/mL (insoluble or slightly soluble)


关键字: inhibit | cuspidatum | Inhibitor | Polygonum | (E/Z) Polydatin | (E/Z)Polydatin | (E/Z)-Polydatin

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相关库: Oxidation-Reduction Compound Library | Bioactive Compounds Library Max | Anti-Obesity Compound Library | Traditional Chinese Medicine Monomer Library | Anti-Cancer Active Compound Library | Anti-COVID-19 Traditional Chinese Medicine Compound Library | Natural Product Library for HTS | Lipid Metabolism Compound Library | Metabolism Compound Library | NO PAINS Compound Library

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注：该产品未在中华人民共和国食品药品监督管理部门申请医疗器械注册和备案，不可用于临床诊断或治疗等相关用途