吴茱萸次碱 T2972

Product Introduction
Bioactivity


英文名: Rutaecarpine

描述: Rutaecarpine (Rhetine) 是从槐木中提取的一种生物碱，是 COX-2的抑制剂，IC50值为0.28 μM。

细胞实验: Rutaecarpine is dissolved in DMSO and diluted with appropriate medium before use. COX-1 and COX-2 cDNA-transfected HEK293 cells are prepared. For measuring inhibitory activity on COX-1 and COX-2 by rutaecarpine, cells in 1 mL of culture medium are seeded into each well of 24-well. After culture for 4 days, the supernatants are removed and 250 mL of fresh medium is added to the cells with or without rutaecarpine. After preincubation for 5 h at 37°C, the cells are further incubated at 37°C for 30 min with 50 mM arachidonic acid. All reactions are stopped by centrifugation at 120 g at 4°C for 5 min. Concentrations of PGE2 in the supernatant are measured[1].

体外活性: Rutaecarpine is an indolopyridoquinazolinone alkaloid isolated from Evodia rutaecarpa and related herbs, which has shown a variety of intriguing biological properties such as anti-thrombotic, anticancer, anti-inflammatory and analgesic, anti-obesity and thermoregulatory, vasorelaxing activity, as well as effects on the cardiovascular and endocrine systems. [1]

存储条件: keep away from direct sunlightPowder: -20°C for 3 years | In solvent: -80°C for 1 year

溶解度: Ethanol : < 1 mg/mL (insoluble or slightly soluble)
DMSO : 18.33 mg/mL (63.81 mM)
H2O : < 1 mg/mL (insoluble or slightly soluble)


关键字: Rutaecarpine | Inhibitor | inhibit | Cyclooxygenase | COX

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相关库: Mitochondria-Targeted Compound Library | Bioactive Compounds Library Max | Inhibitor Library | Traditional Chinese Medicine Monomer Library | Natural Product Library for HTS | Food as Medicine Compound Library | Anti-Pancreatic Cancer Compound Library | Nonsteroidal Anti-Inflammatory Compound Library | Anti-Cardiovascular Disease Compound Library | NO PAINS Compound Library

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注：该产品未在中华人民共和国食品药品监督管理部门申请医疗器械注册和备案，不可用于临床诊断或治疗等相关用途