硫酸软骨素 T2980

Product Introduction
Bioactivity


英文名: Chondroitin sulfate

描述: Chondroitin sulfate (Chonsurid) 是一种糖胺聚糖，被广泛用于骨关节炎的研究。它能够减少炎症介质和凋亡过程，并能够减少炎性细胞因子，iNOS 和MMPs 产生。

细胞实验: Chondrocytes are cultured into six-well culture plates. 12 hours after plating, the culture medium is replaced with 2.0 mL of fresh medium containing LPS at a concentration of 50 mg/mL. 4 hours later, HA, Chondroitin sulfate, HS, keratan sulphate and DS are added separately to each of the wells at concentrations of 0.5 and 1.0 mg/mL. The number of viable chondrocytes is then quantified by trypan blue dye exclusion test from several randomly chosen areas of each well[4].

体外活性: Chondroitin sulfate is a class of sulfated glycosaminoglycans that are linear polysaccharides consisting of repeating disaccharide units composed of uronic acid and N-acetylhexosamine. Several pathogens including parasites, bacteria, and viruses have been shown to utilize cell surface chondroitin sulfate chains to attach to and infect host cells[1]. Chondroitin sulfate occurs naturally in the extracellular matrix of connective tissues, such as bone, cartilage, skin, ligaments and tendons. Chondroitin sulfate has been shown to elicit a range of beneficial effects: anti-inflammatory effects, an increase in type II collagen and proteoglycans, a reduction in bone resorption and a better anabolic/catabolic balance in chondrocytes[2]. A large range of chondroitin sulfate concentrations has been used (e.g. 12.5 to 2000 mg/mL, but generally less than200 mg/mL) in in vitro studies. Chondroitin sulfate (200 mg/mL) decreases the chondrocyte susceptibility to single nucleotide polymorphism-induced apoptosis[3]. Chondroitin sulfate reduces inflammation mediators and the apoptotic process and is able to reduce protein production of inflammatory cytokines, iNOS, MMPs[4].

体内活性: The high content of chondroitin sulfate in the aggrecan plays an important role in allowing cartilage to resist tensile stresses during various loading conditions by providing this tissue with resistance and elasticity. It has been shown that chondroitin sulphate interferes with the progression of structural changes in joint tissues and is used in the management of patients with osteoarthritis[3]. Chondroitin sulfate is mostly administered orally at doses ranging from 800 to 1200 mg/day. Chondroitin sulfate is rapidly absorbed by the gastrointestinal tract. The absorbed chondroitin sulfate reaches the blood compartment as 10% chondroitin sulfate and 90% depolymerized low-molecular-weight derivatives[5].

存储条件: Powder: -20°C for 3 years | In solvent: -80°C for 1 year

溶解度: DMSO : Slightly soluble


关键字: NOS | Matrix metalloproteinases | Nitric oxide synthases | NO Synthase | Chondroitin | Endogenous Metabolite | Chondroitin sulfate | Inhibitor | inhibit | Chondroitin Sulfate | MMP

相关产品: Incyclinide | TMI-1 | Xanthyletin | ethyl rosmarinate | TNO211 | Aloin(mixture of A&B) | Acetohydroxamic acid | Epitheaflagallin 3-O-gallate | Communic acid | Tanomastat

硫酸软骨素 T2980信息由TargetMol中国为您提供，如您想了解更多关于硫酸软骨素 T2980报价、型号、参数等信息，欢迎来电或留言咨询。

注：该产品未在中华人民共和国食品药品监督管理部门申请医疗器械注册和备案，不可用于临床诊断或治疗等相关用途