大戟因子 L1 T2S0410

Product Introduction
Bioactivity


英文名: Euphorbia factor L1

描述: Euphorbia factor L1 (Euphorbiasteroid) 可降低 Bcl-2，PI3K，AKT 和 mTOR 蛋白和 mRNA 水平，上调 caspase-9 and caspase-3 蛋白水平。它可诱导自噬，具有抗癌、抗脂肪生成、抗破骨细胞生成和多重耐药调节作用。

细胞实验: 3T3‐L1 cells were treated with euphorbiasteroid at concentrations of 6.25, 12.5, 25 and 50?μM for 2?days in adipogenesis induction medium, 2?days in adipogenesis medium and 2?days in culture medium (CM) sequentially during differentiation. Intracellular triglycerides (TGs) were stained with Oil red O (ORO) solution.

体外活性: Euphorbiasteroid suppresses adipogenic differentiation of 3T3‐L1 cells, mainly at the early stage, and stimulates the AMPK signalling pathway. The anti-adipogenic effects of euphorbiasteroid could possibly be attributed to activation of the AMPK pathway, by decreasing the level of FAS and its up-regulators, including C/EBPs, PPAR-γ and SREBP-1c, without involving insulin signalling pathway[1]. Euphorbiasteroid could be a transport substrate for P-gp that can effectively inhibit P-gp-mediated drug transport and reverse resistance to anticancer drugs in MES-SA/Dx5 cells[2].

存储条件: Powder: -20°C for 3 years | In solvent: -80°C for 1 year

溶解度: Methanol : Soluble
DMSO : 37 mg/mL(66.9 mM)
Ethanol : Soluble


关键字: Euphorbia factor L-1 | Euphorbia factor L1

相关产品: MI-136 | SGI-1776 | TAI-1 | AAPK-25 | Everolimus | BTR-1 | Nevanimibe hydrochloride | MARK4 inhibitor 1 | Salubrinal | NM-3

相关库: Ion Channel Inhibitor Library | Terpene Natural Product Library | Membrane Protein-targeted Compound Library | Bioactive Compounds Library Max | Neuronal Signaling Compound Library | Anti-Cancer Active Compound Library | Traditional Chinese Medicine Monomer Library | PPI Inhibitor Library | Covalent Inhibitor Library | NO PAINS Compound Library

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注：该产品未在中华人民共和国食品药品监督管理部门申请医疗器械注册和备案，不可用于临床诊断或治疗等相关用途