绞股蓝皂苷 XLVI T2S1593

Product Introduction
Bioactivity


英文名: Gypenoside XLVI

描述: Gypenoside XLVI 是一种来源于绞股蓝的主要达玛烷型三萜皂苷。它具有四环三萜结构，能够有效抑制非小细胞肺癌 A549 细胞的活性。

体外活性: Gynostemma pentaphyllum (Thunb.) Makino is one of the well-known traditional Chinese herbal medicines, which has been demonstrated to be effective against chronic diseases, such as lung cancer. In the present study, seven dammarane-type compounds were isolated from the raw, heat processed and alkaline hydrolyzed G. Pentaphyllum and compared for their cytotoxic activities against non-small cell lung carcinoma A549 cells using MTT cytotoxicity assay. METHODS AND RESULTS: By means of chemical and spectroscopic methods, their structures were established as gypenoside LVI, Gypenoside XLVI, gypenoside L, gypenoside LI, damulin A, damulin B and 20S-dammar-24-en-2α, 3β, 12β, 20-tetrol. Gypenoside LVI, Gypenoside XLVI, gypenoside L, gypenoside LI, damulin A, damulin B and 20S-dammar-24-en-2α,3β,12β,20-tetrol all showed strong cytotoxic activity against A549 cells, with the IC50 values of 105.89±2.48, 52.63±8.31, 34.94±4.23, 50.96±9.55, 26.98±0.51, 4.56±0.58, 12.54±0.53 μg/ml respectively, whereas the IC50 value of 20S-Rg3 (positive control) was 55.36±3.20 μg/ml. Comparing their structures with cytotoxic activity, these compounds might possess some kind of structure-activity relationship. CONCLUSIONS: Based on the structure and cytotoxic activity relationships of these seven constituents, the OH group in C-2, the double bond in C20(21) and C20(22) positions, the connected sugar number and the configuration in C-20 were important for cytotoxic activity against A549 cells.

存储条件: Powder: -20°C for 3 years | In solvent: -80°C for 1 year

溶解度: DMSO : 25 mg/mL (25.96 mM)


关键字: inhibit | Inhibitor | Gypenoside XLVI

相关库: Anti-Tumor Natural Product Library | Anti-Cancer Compound Library | Selected Plant-Sourced Compound Library | Bioactive Compounds Library Max | Anti-Lung Cancer Compound Library | Anti-Cancer Active Compound Library | Traditional Chinese Medicine Monomer Library | Miao medicine Compound Library | NO PAINS Compound Library | Natural Product Library

绞股蓝皂苷 XLVI T2S1593信息由TargetMol中国为您提供，如您想了解更多关于绞股蓝皂苷 XLVI T2S1593报价、型号、参数等信息，欢迎来电或留言咨询。

注：该产品未在中华人民共和国食品药品监督管理部门申请医疗器械注册和备案，不可用于临床诊断或治疗等相关用途