和厚朴酚 T3001

Product Introduction
Bioactivity


英文名: Honokiol

描述: Honokiol (NSC-293100) 是厚朴提取物的活性成分，靶向多种信号分子，具有抗氧化，抗炎，抗血管生成和抗癌活性。它可抑制 Akt 的激活并增强 ERK1/ERK2 的磷酸化。

细胞实验: Honokiol is dissolved in DMSO. In cytotoxicity assays, 10,000 cells/well are added to 96 wells plates and incubated overnight, thereafter cells are treated with different concentrations of Honokiol dissolved in dimethylsulphoxide (DMSO). Since Honokiol is not soluble in aqueous solvents, for in vitro studies Honokiol is dissolved in DMSO. To study the possible effect of DMSO on cells, solvent (DMSO) control is used at highest concentration of <0.1%. After 72 h treatment, cells are fixed and cell viability is measured by crystal violet staining (0.05%).

体外活性: Honokiol抑制小鼠移植瘤RKO细胞生长.Honokiol高效抗裸鼠SVR肉瘤.Honokiol处理小鼠移植瘤,抑制MDA-MD-231乳腺癌细胞生长.

体内活性: Honokiol也具有直接的抗血管生成活性,因为其阻断了由VEGF-VEGFR2相互作用引起的磷酸化和外消旋活化。Honokiol通过激活caspase 8,再激活caspase 9和3,促进CLL细胞凋亡。Honokiol在黑素瘤,肉瘤,骨髓瘤,白血病,膀胱癌,肺癌,前列腺癌,口腔鳞状细胞癌和结肠癌细胞系中显示促细胞凋亡效应。Honokiol有效诱导SVR肉瘤细胞凋亡。Honokiol抑制白细胞介素4介导的CLL细胞存活,并增强苯丁酸氮芥,氟达拉滨和克拉屈滨的细胞毒性。Honokiol以不杀死PBMC的剂量杀死复发患者的骨髓瘤细胞。Honokiol处理SVR细胞,降低MAP,akt和c-src的磷酸化。用Honokiol处理,诱导Caspase 3,7,8和9及PARP裂解。Honokiol诱导结肠癌细胞RKO凋亡。Honokiol通过调节NF-κB活化途径,增强细胞凋亡,抑制破骨细胞生成并抑制侵袭。

存储条件: Powder: -20°C for 3 years | In solvent: -80°C for 1 year

溶解度: Ethanol : 26.6 mg/mL (100 mM)
DMSO : 55 mg/mL (206.51 mM)


关键字: Inhibitor | inhibit | HCV | ERK | Hepatitis C virus | NSC293100 | Autophagy | Protein kinase B | PKB | NSC-293100 | Extracellular signal regulated kinases | Honokiol | Akt

相关产品: Longdaysin | 5α-Hydroxycostic acid | XMD17-109 | JWG-071 | KO-947 | SUN11602 | Ergosterol peroxide | PERK-IN-3 | Isochamaejasmine | (R)-VX-11e

相关库: Drug Repurposing Compound Library | Anti-Cancer Drug Library | Anti-Cancer Clinical Compound Library | Inhibitor Library | Kinase Inhibitor Library | Anti-Colorectal Cancer Compound Library | Traditional Chinese Medicine Monomer Library | Anti-Cancer Active Compound Library | MAPK Inhibitor Library | Natural Product Library

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注：该产品未在中华人民共和国食品药品监督管理部门申请医疗器械注册和备案，不可用于临床诊断或治疗等相关用途