化合物C-DIM12 T3106

Product Introduction
Bioactivity


英文名: C-DIM12

描述: C-DIM12是一种人工合成的Nurr1激活剂，可诱导Nurr1和DA 基因表达。

细胞实验: NF-κB–GFP HEK cells are exposed to 30 ng/ml of TNFα in the presence of 100 μM C-DIM12 for up to 24 hours. C-DIM12 is efficient at blocking NF-κB–GFP expression in the NF-κB–GFP HEK cells after TNFα treatment, displaying a statistically significant reduction in total GFP fluorescence per cell.(Only for Reference)

体外活性: C-DIM12 induces Nurr1 and DA gene expression in cell lines and primary neurons[3]. C-DIM12 suppresses astrocyte inflammatory signaling in vitro. C-DIM12 inhibits lipopolysaccharide (LPS)–induced expression of NF-κB-regulated genes in BV-2 microglia including nitric oxide synthase (NOS2), interleukin-6 (IL-6), and chemokine (C-C motif) ligand 2 (CCL2), and the effects were attenuated by Nurr1-RNA interference. Additionally, C-DIM12 decreased NF-κB activation in NF-κB–GFP (green fluorescent protein) reporter cells and enhanced nuclear translocation of Nurr1 primary microglia. C-DIM12 decreases lipopolysaccharide-induced p65 binding to the NOS2 promoter and concurrently enhanced binding of Nurr1 to the p65-binding site. C-DIM12 also stabilized binding of the Corepressor for Repressor Element 1 Silencing Transcription Factor (CoREST) and the Nuclear Receptor Corepressor 2 (NCOR2)[2].

体内活性: C-DIM12 has the neuroprotective activity in MPTPp-treated mice[2].

存储条件: Powder: -20°C for 3 years | In solvent: -80°C for 1 year

溶解度: DMSO : 35.7 mg/mL (100 mM)
Ethanol : 35.7 mg/mL (100 mM)


关键字: C-DIM12 | inhibit | Inhibitor | C-DIM-12 | CDIM12 | C DIM12 | Apoptosis

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相关库: Anti-Neurodegenerative Disease Compound Library | Bioactive Compounds Library Max | Apoptosis Compound Library | Endocrinology-Hormone Compound Library | Anti-Alzheimer's Disease Compound Library | NO PAINS Compound Library | Bioactive Compound Library

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