化合物K858 T3120

Product Introduction
Bioactivity


英文名: K858 (Racemic)

描述: K858 Racemic (K858) 是一种选择性有丝分裂驱动蛋白 Eg5 抑制剂，以 ATP 非竞争性方式起作用，IC50值为 1.3 μM。

体外活性: K858 is an ATP-uncompetitive inhibitor of Eg5 that is at least 150-fold more selective for Eg5 than other members of the kinesin superfamily. K858 induces mitotic arrest and growth inhibition through the activation of the Mad2-mediated spindle checkpoint. K858 induces mitotic cell death in Y cells but not in normal cells. K858 induces mitotic arrest, apoptosis, and cell growth inhibition and has no effect on microtubule polymerization.

体内活性: K858 exhibits antitumor activity and induces mitotic arrest in a human tumor xenograft mouse model. K858 exhibits antitumor activity and induces mitotic arrest in human xenograft tumor models. [1]

存储条件: Powder: -20°C for 3 years | In solvent: -80°C for 1 year

溶解度: DMSO : 27.7 mg/mL(100 mM)


关键字: inhibit | Inhibitor | K858 (Racemic) | Apoptosis | K-858 (Racemic) | Kinesin | K 858 | K-858 | Racemic

相关产品: Pantoprazole | CCI-007 | AZD-8055 | Pyroxamide | PND-1186 | Angelicin | Fludarabine Phosphate | R406 free base | [6]-Gingerol | AZD-3463

相关库: Anti-Aging Compound Library | Bioactive Compounds Library Max | Inhibitor Library | Cytoskeletal Signaling Pathway Compound Library | Highly Selective Inhibitor Library | Apoptosis Compound Library | NO PAINS Compound Library | Bioactive Compound Library

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注：该产品未在中华人民共和国食品药品监督管理部门申请医疗器械注册和备案，不可用于临床诊断或治疗等相关用途