米屈肼 T3268

Product Introduction
Bioactivity


英文名: Mildronate

描述: Mildronate (Meldonium) 是心血管保护药，能够竞争性的抑制 BBOX1和 OCTN2。作用于人重组 BBOX 的(IC50:34-62 μM)、人 OCTN2 (EC50:21 μM)。它 n 能够诱导长链脂肪酸代谢从线粒体向过氧化物酶体的重定向。

体外活性: Mildronate (40 μM) inhibits the reaction of γ-butyrobetaine hydroxylase with γ-butyrobetaine with Km and Vmax of 36.8 μM and 0.08 nmol/min/mg protein, respectively. [1]

存储条件: Powder: -20°C for 3 years | In solvent: -80°C for 1 year

溶解度: H2O : 10 mM
DMSO : Insoluble


关键字: supplier | glycolysis | β-oxidation | ischaemic | MET88 | mitochondria | inhibit | MET 88 | Inhibitor | MET-88 | Mildronate | peroxisomes

相关产品: Sapropterin dihydrochloride | GSK 366 | Casein | p-Fluoro-L-phenylalanine | Telotristat ethyl | Diethyl-pythiDC | Telotristat Etiprate | Telotristat | LPA2 antagonist 1 | Nepicastat hydrochloride

相关库: Drug Repurposing Compound Library | Approved Drug Library | ReFRAME Related Library | Clinical Compound Library | Bioactive Compounds Library Max | Human Metabolite Library | Inhibitor Library | Metabolism Compound Library | Anti-Cardiovascular Disease Compound Library | NO PAINS Compound Library

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注：该产品未在中华人民共和国食品药品监督管理部门申请医疗器械注册和备案，不可用于临床诊断或治疗等相关用途