化合物LM-1685 T32824

Product Introduction
Bioactivity


英文名: LM-1685

描述: LM-1685是一种有效且具有选择性的人单核细胞和全血中COX-2抑制剂，IC50分别为0.65 µM 和IC50 = 4.3 μM，是治疗炎症的潜在化合物。

体外活性: We found that continuous exposure to cytostatic doses of CAI and LM-1685, a celecoxib analog, reduced the proliferation and survival of seven human cancer cell lines by at least one log (P < or = 0.001) over either agent alone. The supra-additive antiproliferative effects occurred throughout a range of LM-1685 doses (5-25 micromol/L) and paralleled a decrease in COX-2 activity as measured by prostaglandin E2 production. In these cells, treatment with LM-1685/CAI suppressed the extracellular signal-regulated kinase pathway within the first hour but ultimately results in high, sustained activation of ERK over a 9-day period (P = 0.0005). [1]

存储条件: Powder: -20°C for 3 years | In solvent: -80°C for 1 year

溶解度: DMSO : 90.0 mg/mL (238.2 mM)
Methanol : 0.9 mg/mL (2.3 mM)


关键字: LM-1685

相关产品: Taiwanhomoflavone A | Pectolinarigenin | Zileuton | CAY10404 | Phenylbutazone | Samidin | 4-Methylamino antipyrine hydrochloride | Goshonoside F5 | (-)-Catechin | Desoxo-narchinol A

相关库: Anti-Cancer Compound Library | Bioactive Compounds Library Max | Neuronal Signaling Compound Library | Inhibitor Library | Bioactive Compound Library

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注：该产品未在中华人民共和国食品药品监督管理部门申请医疗器械注册和备案，不可用于临床诊断或治疗等相关用途