齐墩果酮酸 T3321

Product Introduction
Bioactivity


英文名: Oleanonic acid

描述: Oleanonic acid (3-Ketooleanolic Acid) 是一种三萜，可以抑制 HIV-1 对细胞的感染。它具有保肝作用，并具有抗肿瘤和抗病毒特性。

激酶实验: Cerebral cortices from male Sprague-Dawley rats (200-300 g) are homogenized in 9 volumes of ice-cold 0.32mol/Lsucrose by nine strokes with a Teflon/glass homogenizer at 500 rpm. The homogenate is centrifuged for 10 min at 1×103 g, and the supernatant is recentrifuged at 1×104 g for 20 min at 4°C. The pellet is suspended in assay buffer (118 mM NaCl/4.7 mM KCl/1.2 mM MgSO4/5 mM NaHCO3/20 mM Hepes/1.2 mM KH2PO4/2.5 mM CaCl2/11 mM glucose, pH 7.4) and incubated at 23°C for 20 min prior to final centrifugation at 1×103 g for 20 min at 4°C. The pellet is resuspended in assay buffer (70 mL per gram of original tissue). Binding of [3H]MK-801 is measured by incubating 750 μL duplicate aliquots of this crude membrane suspension (=0.75 mg of protein) with 100 μL of buffer containing displacer or of buffer alone (total binding), 100 μL of 50 nM [3H]MK-801, and 50 μL of buffer for 60 min at 23°C. Nonspecific binding is defined by 100 μM (final concentration) unlabeled MK-801.

存储条件: Powder: -20°C for 3 years | In solvent: -80°C for 1 year

溶解度: DMSO : 100 mg/mL (219.93 mM)
H2O : < 0.1 mg/mL (insoluble)


关键字: HIV | Human immunodeficiency virus | inhibit | Inhibitor | Oleanonic acid

相关产品: Diphyllin | Salicylanilide | Oleanolic Acid | Pomolic acid | Enfuvirtide acetate | Ursonic Acid | HIV-1 protease-IN-12 | IMB-301 | P-113 acetate | 16beta,17-Dihydroxy-ent-kaurane-19-oic acid

相关库: Anti-Tumor Natural Product Library | Anti-COVID-19 Compound Library | Anti-Cancer Compound Library | Traditional Chinese Medicine Monomer Library | Anti-Cancer Active Compound Library | Natural Product Library for HTS | NO PAINS Compound Library | Anti-Viral Compound Library | Anti-infective Natural Product Library | Bioactive Compound Library

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注：该产品未在中华人民共和国食品药品监督管理部门申请医疗器械注册和备案，不可用于临床诊断或治疗等相关用途