甲苯地尔 T33272

Product Introduction
Bioactivity


英文名: Mefenidil

描述: Mefenidil (McN-2378) 是一种选择性脑血管扩张剂，在狗麻醉模型中显示出在不刺激 O2 摄取的情况下增加健康大脑中的 CBF。

体内活性: Mefenidil (0.025, 0.25, and 2.5 mg/min/kg; i.v. infusion for 10 min; dogs) decreased systemic vascular resistance at 0.25 mg/min/kg without a change in CBF. At the highest infusion rate, CBF increased by 54 +/- 15% (+/- S.E.; n = 9) accompanied by a 9-mm Hg rise in intracranial pressure and a 14-mm Hg fall in mean aortic pressure. However, cardiac output increased by 68 +/- 8%, which was distributed primarily to right ventricle (541 +/- 95%), left ventricle (488 +/- 109%), small intestine (136 +/- 31%) and large intestine (57 +/- 15%). Within the brain, the thalamic and brainstem regions had larger increases in blood flow than the cerebellum and cerebrum. The caudate nucleus had a greater percentage of response than white matter. Using the cerebral venous outflow technique in another series of seven dogs, mefenidil (40-mg/kg i.v. bolus) produced a 20 +/- 8% increase in CBF with no change in O2 uptake. These data show that mefenidil is capable of increasing CBF in healthy brains without stimulating O2 uptake. However, the clinical usefulness of mefenidil as a cerebral vasodilator may be limited by the accompanying arterial hypotension due to systemic vasodilation, which was most prominent in the heart and gut.[1]

存储条件: Powder: -20°C for 3 years | In solvent: -80°C for 1 year

溶解度: DMSO : 50 mg/mL (253.5 mM)


关键字: Mefenidil | McN2378

相关库: Anti-Cancer Compound Library | Bioactive Compounds Library Max | Bioactive Compound Library

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注：该产品未在中华人民共和国食品药品监督管理部门申请医疗器械注册和备案，不可用于临床诊断或治疗等相关用途