烟酰胺核糖三氟甲磺酸酯 T33663

Product Introduction
Bioactivity


英文名: Nicotinamide Riboside Triflate

描述: Nicotinamide Riboside Triflate (SRT647 Triflate) 是一种天然NAD前体，可增加NAD水平，可增强氧化代谢并防止高脂肪饮食引起的肥胖，KE 激活SIRT3可防止噪音引起的听力损失,可用于研究肌肉萎缩。

体外活性: Nicotinamide Riboside Triflate (1-1000 μM; HEK293T cells) exhibits a concentration-dependent increase in intracellular and mitochondrial NAD+ content in C2C12, Hepa1.6, and HEK293 cells.[1] Nicotinamide Riboside Triflate (0.5 nM; 24 h; HEK293T cells) reduces the acetylation status of Ndufa9 and SOD2.[1] Nicotinamide Riboside Triflate enhances NAD levels to reinstate the antiviral poly(ADP-ribose) polymerase (PARP) functions, bolstering innate immunity against coronaviruses (CoVs), a contributing factor to COVID-19.[3]

体内活性: Nicotinamide Riboside Triflate（400 mg/kg/天；口服；持续16周；10周龄C57Bl/6J小鼠）导致血浆和细胞内NAD+水平在特定组织中的增加。[1]

存储条件: store at low temperaturePowder: -20°C for 3 years | In solvent: -80°C for 1 year

关键字: Nicotinamide Riboside Triflate

相关产品: SRT 1460 | MC3482 | 3-TYP | SIRT1 activator 1 | Salvianolic acid B | Dihydrocoumarin | Selisistat | SRT 2183 | Sirt1/2-IN-4 | Scopolin

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注：该产品未在中华人民共和国食品药品监督管理部门申请医疗器械注册和备案，不可用于临床诊断或治疗等相关用途