NM-3(异香豆素) T33701

Product Introduction
Bioactivity


英文名: NM-3

描述: NM-3 是一种可口服的抗血管生成的抑制剂，具有抗肿瘤活性。NM-3在体外和体内可当作辐射调节剂使用。NM-3抑制血管内皮生长因子（VEGF），从而抑制内皮细胞的增殖。NM-3与活性氧的机制诱导细胞凋亡有关。

体外活性: NM-3（100 ng/ml）对人脐静脉内皮细胞（HUVECs）具有细胞毒性，但在克隆存活实验中，对Lewis肺癌细胞（LLC）和食管腺癌细胞Seg-1（1,000 ng/ml；4h）则无此作用。[1]

体内活性: C57BL/6 female mice bearing LLC tumors were given injections for 4 consecutive days with NM-3 (25 mg/kg/day) and treated with IR (20 Gy) for 2 consecutive days. Combined treatment with NM-3 and IR significantly reduced mean tumor volume compared with either treatment alone. An increase in local tumor control was also observed in LLC tumors in mice receiving NM-3/IR therapy. When athymic nude mice bearing Seg-1 tumor xenografts were treated with NM-3 (100 mg/kg/day for 4 days) and 20 Gy (four 5 Gy fractions), significant tumor regression was observed after combined treatment (NM-3 and IR) compared with IR alone. Importantly, no increase in systemic or local tissue toxicity was observed after combined treatment (NM-3 and IR) when compared with IR alone. The bioavailability and nontoxic profile of NM-3 suggests that the efficacy of this agent should be tested in clinical radiotherapy.[1]

存储条件: Powder: -20°C for 3 years | In solvent: -80°C for 1 year

溶解度: DMSO : 27.5 mg/mL (104.08 mM)


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相关库: Mitochondria-Targeted Compound Library | Anti-Cancer Compound Library | NF-κB Signaling Compound Library | Bioactive Compounds Library Max | Inhibitor Library | Anti-Cancer Active Compound Library | Bioactive Compound Library

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