二氢丹参酮 I T3374
品牌 | 厂商性质 | 产地 | 货期 |
---|---|---|---|
TargetMol | 生产商 | 美国 | 现货 |
性能特点
生化试剂,可用于动物细胞实验
规格 | CAS号 | 价格 | 操作 |
---|---|---|---|
50 mg | 87205-99-0 | ¥2,430.00 | 询底价 |
25 mg | 87205-99-0 | ¥1,680.00 | 询底价 |
500 mg | 87205-99-0 | ¥8,120.00 | 询底价 |
5 mg | 87205-99-0 | ¥455.00 | 询底价 |
100 mg | 87205-99-0 | ¥3,790.00 | 询底价 |
10 mg | 87205-99-0 | ¥819.00 | 询底价 |
1 mg | 87205-99-0 | ¥198.00 | 询底价 |
Product Introduction
Bioactivity
英文名: Dihydrotanshinone I
描述: Dihydrotanshinone I (DHTS) 是从丹参中分离到的一种天然产物,可抑制 MERS-CoV,可研究心血管疾病。
激酶实验: Cells are treated with various concentrations of Dihydrotanshinone I (3.13-20 μM) for 48 h. For the activity assay, Ac-DEVD-AMC (1 μg/μL), Ac-IETD-AMC (1 μg/μL) or Ac-LEDH-AMC (1 μg/μL) and cell lysate are added into Protease Assay Buffer in 96-well plate. Reaction mixtures with lysis buffer are used as negative controls. Cells treated with DMSO (0.1%) are treated as vehicle control. The reaction mixtures are incubated for 1 h at 37°C. The AMC liberated from the substrates is measured using spectrofluorometer of Victor 2 plate reader with an excitation wavelength of 380 nm and an emission wavelength of 430 nm.
体外活性: DHT (10 nM) decreases lectin-like ox-LDL receptor-1 (LOX-1) and NADPH oxidase 4 (NOX4) expression, reactive oxygen species (ROS) production, NF-κB nuclear translocation, ox-LDL endocytosis and monocytes adhesion in lipopolysaccharide (LPS)-stimulated human umbilical vein endothelial cells (HUVECs)[1]. Dihydrotanshinone I induces caspase-dependent apoptosis induced in HCT116 cells. Dihydrotanshinone I induces concentration and ROS dependent caspase activation. Apoptosis induced by Dihydrotanshinone I is completely prevented by Z-VAD-fmk. Apoptosis induced by Dihydrotanshinone I is significantly inhibited by pretreatment of Z-LEHD-fmk but only is partially inhibited by Z-IETD-fmk. Apoptosis induced by Dihydrotanshinone I is significantly increased by caspase-2 knockdown[3].
体内活性: In ApoE-/- mice fed with an atherogenic diet, DHT (10 and 25 mg kg-1) significantly attenuated atherosclerotic plaque formation, altered serum lipid profile, decreased oxidative stress and shrunk necrotic core areas. DHT dramatically inhibits the enhanced expression of LOX-1, NOX4, and NF-κB in aorta[1]. Dihydrotanshinone I (1, 2, 4 mg/kg) treatment can improve cardiac function, reduce infarct size, ameliorate the variations in myocardial zymogram and histopathological disorders, decrease 20-HETE generation, and regulate apoptosis-related protein in myocardial ischemia-reperfusion rats[2].
存储条件: Powder: -20°C for 3 years | In solvent: -80°C for 1 year
溶解度: DMSO : 3.85 mg/mL (13.82 mM)
关键字: SARS coronavirus | inhibit | SARS-CoV | Dihydrotanshinone I | Inhibitor
相关产品: TC-067533 | SARS-CoV-2 3CLpro-IN-18 | SARS-CoV-2-IN-47 | GS-443902 | Narsoplimab | Ledipasvir | SARS-CoV-2 nsp14-IN-3 | Sivelestat | D-4-77 | TKB245
相关库: Anti-Aging Compound Library | Antioxidant Compound Library | Pyroptosis Compound Library | Oxidation-Reduction Compound Library | Selected Plant-Sourced Compound Library | Traditional Chinese Medicine Monomer Library | Lipid Metabolism Compound Library | Cuproptosis Compound Library | Anti-Infection Compound Library | Anti-infective Natural Product Library
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注:该产品未在中华人民共和国食品药品监督管理部门申请医疗器械注册和备案,不可用于临床诊断或治疗等相关用途