葫芦素 B T3404
品牌 | 厂商性质 | 产地 | 货期 |
---|---|---|---|
TargetMol | 生产商 | 美国 | 现货 |
性能特点
生化试剂,可用于动物细胞实验
规格 | CAS号 | 价格 | 操作 |
---|---|---|---|
10 mg | 6199-67-3 | ¥1,330.00 | 询底价 |
1 mL | 6199-67-3 | ¥935.00 | 询底价 |
50 mg | 6199-67-3 | ¥3,970.00 | 询底价 |
5 mg | 6199-67-3 | ¥742.00 | 询底价 |
25 mg | 6199-67-3 | ¥2,760.00 | 询底价 |
1 mg | 6199-67-3 | ¥318.00 | 询底价 |
100 mg | 6199-67-3 | ¥5,850.00 | 询底价 |
Product Introduction
Bioactivity
英文名: Cucurbitacin B
描述: Cucurbitacin B (Cuc B) 是一具有抗癌活性的天然产物。
细胞实验: For proliferation measurements, the cells are placed into 96 well plates, and cell growth is measured at various times by MTT assay according to the protocol.(Only for Reference)
体外活性: Cucurbitacin B inhibits the growth of 5 GBM cell lines: U87, U118, U343, U373 and T98 g by affecting the cytoskeleton and the JNK pathway, with ED50 ranged from 5 nM to 100 nM. Cucurbitacin B also causes cell cycle arrest at the G2/M phase, decreases cell migration and induces apoptosis of GBM cells. [1] In human breast cancer cell lines, Cucurbitacin B also inhibits cell growth with ED50 varied from 30.3 nM to 418 nM, and rapidly induces cytoskeletal disruption. [2] In addition, Cucurbitacin B possesses immunomodulatory and anti-inflammatory effects, depending on the induction of heme oxygenase-1 expression via Nrf2 activation. [3]
体内活性: 在裸鼠体内携带MDA-MB-231肿瘤时,Cucurbitacin B(1 mg/kg,i.p.)通过抑制肿瘤生长55%,同时降低血清中的葡萄糖水平。[2]
存储条件: Powder: -20°C for 3 years | In solvent: -80°C for 1 year
溶解度: DMSO : 91 mg/mL(162.9 mM)
Chloroform, Dichloromethane, Ethyl Acetate : Soluble
Ethanol : 50 mg/mL (89.49 mM)
关键字: Inhibitor | Integrin | Apoptosis | inhibit | Endogenous Metabolite | Autophagy | Cucurbitacin B
相关产品: Citric acid | Pogostone | Terrestrosin D | Cucurbitacin IIb | Antitumor agent-97 | Methyl-4-oxoretinoate | Ganoderic acid A | PF-3758309 | β-Ionone | LJH685
相关库: Antioxidant Compound Library | PI3K-AKT-mTOR Compound Library | Angiogenesis related Compound Library | Phosphatase Inhibitor Library | Inhibitor Library | Cytoskeletal Signaling Pathway Compound Library | Anti-Cancer Active Compound Library | Traditional Chinese Medicine Monomer Library | Reprogramming Compound Library | Glycolysis Compound Library
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注:该产品未在中华人民共和国食品药品监督管理部门申请医疗器械注册和备案,不可用于临床诊断或治疗等相关用途