6-姜酚 T3405

Product Introduction
Bioactivity


英文名: [6]-Gingerol

描述: [6]-Gingerol ((S)-(+)-[6]Gingerol) 是一种从生姜中分离的活性物质，具有抗癌，抗炎和抗氧化活性。

细胞实验: [6]-gingerol stock (20 mg/mL) is prepared in ethanol and the working concentrations are prepared by diluting this stock in dimethyl sufoxide (DMSO). For MTT assay, 5×103 cells/well of human colon cancer cells and 104 cells/well of mouse IECs are seeded in 96-well plates. Cells are treated with [6]-gingerol for 48 h,72 h or 96 h before performing MTT assay and for 16 h before Annexin-V staining[1].

体外活性: [6]-gingerol inhibits colon cancer cell proliferation and induced apoptosis without affecting the normal colon cells. [6]-gingerol down-regulates phorbol myristate acetate induced phosphorylation of ERK1/2 and JNK MAP kinases and activation of AP-1 transcription factor, but has only little effects on phosphorylation of p38 MAP kinase and activation of NF-kappa B[1]. [6]-gingerol treatment is shown to restore impaired intestinal barrier function and to suppress proinflammatory responses in DSS-treated Caco-2 monolayers. AMPK is activated on [6]-gingerol treatment[2]. Treatment with [6]-gingerol results in a significant decrease in the viability of osteosarcoma cells in a dose-dependent fashion. In parallel, the number of cells arrested at the sub-G1 cell cycle phase is significantly increased. [6]-gingerol induces activation of caspase cascades and regulates cellular levels of Bcl2 and Bax[3].

体内活性: 在动物研究中，[6]-Gingerol 显著改善了DSS诱导的结肠炎症，表现为体重损失的恢复、肠道出血的减少以及预防结肠长度缩短。此外，[6]-Gingerol 还抑制了DSS提高的促炎细胞因子（IL-1β、TNFα和IL-12）[2]的产生。

存储条件: store at low temperature,keep away from direct sunlightPowder: -20°C for 3 years | In solvent: -80°C for 1 year

溶解度: Chloroform, Dichloromethane, Ethyl Acetate, Acetone, etc. : Soluble
DMSO : 53 mg/mL(180 mM)


关键字: AMP-activated protein kinase | Apoptosis | inhibit | [6] Gingerol | [6]-Gingerol | AMPK | [6]Gingerol | Inhibitor

相关产品: Kaerophyllin | Alginic acid | STAT3-IN-11 | Rhapontin | Neobavaisoflavone | Ginsenoside Rk1 | Metronidazole | WP1066 | AZ 628 | KRAS inhibitor-9

相关库: Marine Natural Product Library | Selected Plant-Sourced Compound Library | Kinase Inhibitor Library | Anti-Obesity Compound Library | Anti-Diabetic Compound Library | Traditional Chinese Medicine Monomer Library | Anti-Cancer Active Compound Library | Apoptosis Compound Library | RO5 Drug-like Natural Product Library | Reprogramming Compound Library

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注：该产品未在中华人民共和国食品药品监督管理部门申请医疗器械注册和备案，不可用于临床诊断或治疗等相关用途