PI3-Kinase α Inhibitor 2 T35525
品牌 | 厂商性质 | 产地 | 货期 |
---|---|---|---|
TargetMol | 生产商 | 美国 | 现货 |
性能特点
生化试剂,可用于动物细胞实验
规格 | CAS号 | 价格 | 操作 |
---|---|---|---|
500 μg | 371943-05-4 | ¥490.00 | 询底价 |
5 mg | 371943-05-4 | ¥3,620.00 | 询底价 |
10 mg | 371943-05-4 | ¥6,240.00 | 询底价 |
1 mg | 371943-05-4 | ¥875.00 | 询底价 |
Product Introduction
Bioactivity
英文名: PI3-Kinase α Inhibitor 2
描述: Phosphatidylinositol 3-kinase (PI3K) catalyzes the phosphorylation of the 3' hydroxyl position of PIs to produce the second messengers PtdIns-(3,4)-P2 and PtdIns-(3,4,5)-P3. PI3Kα, β, and δ are class 1A enzymes composed of p110 and p85 subunits, whereas PI3Kγ is a class 1B PI3K composed of a p110 catalytic subunit and a p101 or p84 regulatory subunit. PI3Kα inhibitor 2 is a selective inhibitor of PI3Kα with IC50 values of 2, 16, 660, and 220 nM for the α, β, γ, and 2Cβ isoforms, respectively. It inhibits PKA, KDR, PKCα, and cyclin E/Cdk2 significantly less effectively (IC50 = 91, 3.4, 466, and 28 μM, respectively). PI3Kα inhibitor 2 inhibits A375 melanoma cell proliferation with an IC50 value of 580 nM.
存储条件: Powder: -20°C for 3 years | In solvent: -80°C for 1 year
溶解度: DMSO : 25 mg/mL
DMF:PBS(pH 7.2) (1:3) : 0.25 mg/mL
DMF : 30 mg/mL
Ethanol : 1 mg/mL
关键字: PI3 Kinase α Inhibitor 2 | PI-3-Kinase α Inhibitor 2 | PI3Kinase α Inhibitor 2 | PI3-Kinase a Inhibitor 2 | PI3-Kinase alpha Inhibitor 2
PI3-Kinase α Inhibitor 2 T35525信息由TargetMol中国为您提供,如您想了解更多关于PI3-Kinase α Inhibitor 2 T35525报价、型号、参数等信息,欢迎来电或留言咨询。
注:该产品未在中华人民共和国食品药品监督管理部门申请医疗器械注册和备案,不可用于临床诊断或治疗等相关用途