Hedgehog Antagonist VIII T35537

Product Introduction
Bioactivity


英文名: Hedgehog Antagonist VIII

描述: Hedgehog (Hh) proteins, important regulators of development, bind the cell-surface protein Patched, allowing activation of Smoothened. In vertebrates, this ultimately leads to the activation of the zinc-finger transcription factors of the Gli family. Overactivation of this pathway contributes to certain cancers, including glioblastoma, for which the Gli proteins are named. Hh antagonist VIII is a cell-permeable quinazolinyl-urea compound that has been shown to inhibit Gli transcription activity with an IC50 value of 70 nM.

存储条件: Powder: -20°C for 3 years | In solvent: -80°C for 1 year

溶解度: Ethanol : 10 mg/mL
DMF : 30 mg/mL
DMF:PBS(pH7.2) (1:2) : 0.3 mg/mL
DMSO : 25 mg/mL


关键字: Hedgehog Antagonist VIII

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注：该产品未在中华人民共和国食品药品监督管理部门申请医疗器械注册和备案，不可用于临床诊断或治疗等相关用途