2,5-二甲基塞来考昔 T35610
品牌 | 厂商性质 | 产地 | 货期 |
---|---|---|---|
TargetMol | 生产商 | 美国 | 现货 |
性能特点
生化试剂,可用于动物细胞实验
规格 | CAS号 | 价格 | 操作 |
---|---|---|---|
5 mg | 457639-26-8 | ¥1,380.00 | 询底价 |
500 mg | 457639-26-8 | ¥13,600.00 | 询底价 |
50 mg | 457639-26-8 | ¥4,930.00 | 询底价 |
2 mg | 457639-26-8 | ¥823.00 | 询底价 |
1 mg | 457639-26-8 | ¥562.00 | 询底价 |
100 mg | 457639-26-8 | ¥6,830.00 | 询底价 |
25 mg | 457639-26-8 | ¥3,460.00 | 询底价 |
10 mg | 457639-26-8 | ¥1,980.00 | 询底价 |
Product Introduction
Bioactivity
英文名: 2,5-dimethyl Celecoxib
描述: 2,5-dimethyl Celecoxib 是塞来昔布衍生物和微粒体前列腺素 E 合酶 1 (mPGES-1) 的靶向抑制剂,mPGES-1 是炎症介质 PGE2 合成途径中的关键酶。
体外活性: 2,5-dimethyl Celecoxib(1–100?μM) decreased the viability of GBM cell lines in a dose-dependent manner. 2,5-dimethyl Celecoxib downregulated β-catenin target genes expression in A-172, T98G and U-138 MG cell lines. Apoptosis was induced, and cell cycle distribution was altered after the treatment with 2,5-dimethyl Celecoxib in T98G cell line.2,5-dimethyl Celecoxib downregulated β-catenin target genes expression in patient-derived primary GBM cell lines P1 and P6[1].
体内活性: 2,5-dimethyl Celecoxib prevented cardiac remodeling and markedly reduced urinary albumin excretion without altering blood pressure in mice. 2,5-dimethyl Celecoxib prevented podocyte injury, glomerulosclerosis, and interstitial fibrosis in the kidney of mice loaded with angiotensin II and high-salt load. 2,5-dimethyl Celecoxib reduced the phosphorylation level of Akt and activated glycogen synthase kinase-3, which led to the suppression of the Wnt/β-catenin signal in the heart and kidney. 2,5-dimethyl Celecoxib also reduced the expression level of snail, a key transcription factor for the epithelial–mesenchymal transition and of which gene is a target of the Wnt/β-catenin signal[2].
存储条件: Powder: -20°C for 3 years | In solvent: -80°C for 1 year
溶解度: Ethanol : 3 mg/mL
DMSO : 5 mg/mL
DMF : 5 mg/mL
DMSO:PBS (pH 7.2) (1:3) : 0.25 mg/mL
关键字: 2,5-dimethyl Celecoxib | 2,5dimethyl Celecoxib | 2,5 dimethyl Celecoxib
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相关库: Anti-Cancer Metabolism Compound Library | Neuronal Differentiation Compound Library | Membrane Protein-targeted Compound Library | Bioactive Compounds Library Max | Anti-Ovarian Cancer Compound Library | Inhibitor Library | GPCR Compound Library | Anti-Obesity Compound Library | Anti-Colorectal Cancer Compound Library | Bioactive Compound Library
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注:该产品未在中华人民共和国食品药品监督管理部门申请医疗器械注册和备案,不可用于临床诊断或治疗等相关用途