Photoswitchable PAD Inhibitor (technical grade) T35817
品牌 | 厂商性质 | 产地 | 货期 |
---|---|---|---|
TargetMol | 生产商 | 美国 | 现货 |
性能特点
生化试剂,可用于动物细胞实验
规格 | CAS号 | 价格 | 操作 |
---|---|---|---|
5 mg | 2226393-62-8 | ¥13,700.00 | 询底价 |
500 μg | 2226393-62-8 | ¥2,110.00 | 询底价 |
1 mg | 2226393-62-8 | ¥3,370.00 | 询底价 |
Product Introduction
Bioactivity
英文名: Photoswitchable PAD Inhibitor (technical grade)
描述: Photoswitchable PAD inhibitor is a photoactivated protein arginine deiminase (PAD) inhibitor and a derivative of BB-Cl-amidine that contains an azobenzene photoswitch allowing optical control of PAD activity.1 Without photoactivation, it is a weak inhibitor of PAD2 (IC50 = >100 μM) and is less potent than BB-Cl-amidine in inhibiting citrulline production in vitro (kinact/KIs = 2,300, 600, 1,000, and 10,510 M-1min-1 for PAD1-4, respectively) and does not inhibit histone H3 citrullination in HEK293T cells overexpressing PAD2 when used at concentrations up to 100 μM. However, it can rapidly be photoactivated with UV-A radiation to the more active cis-isomer, which is an irreversible, competitive inhibitor of histone H3 citrullination with an IC50 value of 9.1 μM.
存储条件: Powder: -20°C for 3 years | In solvent: -80°C for 1 year
溶解度: Methanol : 30 mg/mL
关键字: technical grade | Photoswitchable PAD Inhibitor (technical grade) | Photoswitchable PAD Inhibitor
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注:该产品未在中华人民共和国食品药品监督管理部门申请医疗器械注册和备案,不可用于临床诊断或治疗等相关用途