(±)5(6)-EET T36070
品牌 | 厂商性质 | 产地 | 货期 |
---|---|---|---|
TargetMol | 生产商 | 美国 | 现货 |
性能特点
生化试剂,可用于动物细胞实验
规格 | CAS号 | 价格 | 操作 |
---|---|---|---|
500 μg | 87173-80-6 | ¥7,640.00 | 询底价 |
100 μg | 87173-80-6 | ¥2,460.00 | 询底价 |
25 μg | 87173-80-6 | ¥787.00 | 询底价 |
50 μg | 87173-80-6 | ¥1,410.00 | 询底价 |
Product Introduction
Bioactivity
英文名: (±)5(6)-EET
描述: 5(6)-EET is a fully racemic version of the enantiomeric forms biosynthesized from arachidonic acid by cytochrome P450 enzymes. In solution, 5(6)-EET degrades into 5,6-DiHET and 5(6)-δ-lactone, which can be converted to 5(6)-DiHET and quantified by GC-MS. In neuroendocrine cells, such as the anterior pituitary and pancreatic islets, 5(6)-EET has been implicated in the mobilization of calcium and hormone secretion. 5(6)-EET is an inhibitor of T-type voltage-gated calcium channels (Cav3) that inhibits isoforms Cav3.1, Cav3.2 (IC50 = 0.54 μM), and Cav3.3 and decreases nifedipine-resistant phenylephrine-induced vasoconstriction in isolated mouse mesenteric arteries via Cav3.2 blockade when used at a concentration of 3 μM. In addition, it is a substrate of COX-1 and COX-2, as measured by oxygen consumption and product formation assays when used at a concentration of 50 μM. (±)5(6)-EET is provided as a mixture of the free acid and lactone.
存储条件: Powder: -20°C for 3 years | In solvent: -80°C for 1 year
溶解度: DMSO : >50 mg/mL (per Rao Maddipati)
Ethanol : >50 mg/mL (per Rao Maddipati)
DMF : >50 mg/mL (per Rao Maddipati)
PBS (pH 7.2) : >1 mg/mL (from 13(S)-HODE)
关键字: 5(6)-EET | (±)5(6) EET | (±)5(6)EET
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注:该产品未在中华人民共和国食品药品监督管理部门申请医疗器械注册和备案,不可用于临床诊断或治疗等相关用途