化合物 TMP-153 T36126
品牌 | 厂商性质 | 产地 | 货期 |
---|---|---|---|
TargetMol | 生产商 | 美国 | 现货 |
性能特点
生化试剂,可用于动物细胞实验
规格 | CAS号 | 价格 | 操作 |
---|---|---|---|
1 mg | 128831-46-9 | ¥1,980.00 | 询底价 |
50 mg | 128831-46-9 | ¥13,800.00 | 询底价 |
25 mg | 128831-46-9 | ¥10,600.00 | 询底价 |
5 mg | 128831-46-9 | ¥4,920.00 | 询底价 |
2 mg | 128831-46-9 | ¥2,970.00 | 询底价 |
10 mg | 128831-46-9 | ¥7,130.00 | 询底价 |
Product Introduction
Bioactivity
英文名: TMP-153
描述: Acyl-CoA:cholesterol acyltransferase (ACAT) catalyses the esterification of excess cellular cholesterol with fatty acids and is important for intestinal cholesterol absorption, hepatic lipoprotein secretion, and cholesterol accumulation in vascular tissues. ACAT inhibitors improve plasma lipid profile and ameliorate proteinuria in nephrotic animals. TMP-153 is a quinolyl derivative that inhibits ACAT with IC50 values of 5-10 nM in various animals. At 0.5-1.5 mg/kg, TMP-153 dose-dependently reduces plasma total- and low density lipoprotein cholesterol without affecting high density lipoprotein cholesterol in hamsters. It inhibits cholesterol esterification both in human colonic adenocarcinoma L S180 cells and in human hepatoma HepG2 cells (IC50s = 150 and 330 nM, respectively). When fed as a dietary supplement (ED50 = 0.81 mg/kg/day), TMP-153 reduces hepatic cholesterogenesis in hamsters fed a stock diet.
存储条件: Powder: -20°C for 3 years | In solvent: -80°C for 1 year
溶解度: DMF : 10 mg/mL
DMSO : 30 mg/mL
关键字: TMP153 | TMP 153 | TMP-153
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注:该产品未在中华人民共和国食品药品监督管理部门申请医疗器械注册和备案,不可用于临床诊断或治疗等相关用途