2-chloro Palmitic Acid T36221

Product Introduction
Bioactivity


英文名: 2-chloro Palmitic Acid

描述: 2-chloro Palmitic acid is a monochlorinated form of palmitic acid . It is produced in a myeloperoxidase (MPO) and time-dependent manner in neutrophils stimulated by phorbol 12-myristate 13-acetate . 2-chloro Palmitic acid (10 μM) induces neutrophil extracellular trap (NET) formation (NETosis) in human neutrophils, increasing DNA release from neutrophils, colocalization of MPO with extracellular DNA (ecDNA), and trapping of E. coli. It increases COX-2 protein levels in human coronary artery endothelial cells (HCAECs) when used at a concentration of 50 μM and increases production of P-selectin, von Willebrand factor, and angiopoietin-2 in HCAECs, as well as neutrophil and platelet adherence, when used at a concentration of 10 μM. 2-chloro Palmitic acid (10-50 μM) also induces apoptosis in THP-1 cells and primary human monocytes and increases caspase-3 activity in THP-1 cells.

存储条件: Powder: -20°C for 3 years | In solvent: -80°C for 1 year

溶解度: DMF : 20 mg/mL
DMSO : 20 mg/mL
Ethanol : 30 mg/mL
Ethanol:PBS (pH 7.2) (1:3) : 0.25 mg/mL


关键字: 2chloro Palmitic Acid | 2 chloro Palmitic Acid | 2-chloro Palmitic Acid

2-chloro Palmitic Acid T36221信息由TargetMol中国为您提供，如您想了解更多关于2-chloro Palmitic Acid T36221报价、型号、参数等信息，欢迎来电或留言咨询。

注：该产品未在中华人民共和国食品药品监督管理部门申请医疗器械注册和备案，不可用于临床诊断或治疗等相关用途