SJF 8240 T36246

Product Introduction
Bioactivity


英文名: SJF 8240

描述: c-MET degrader. Comprises MET inhibitor foretinib (GSK 1363089) joined by a linker to a von Hippel-Lindau (VHL) recruiting ligand. Degrades c-MET within 6 hours in vitro. Inhibits agonist-driven AKT phosphorylation and GTL16 cell proliferation (IC50 = 66.7 nM). Also degrades exon-14-deleted c-MET in Hs746T cells.

存储条件: Powder: -20°C for 3 years | In solvent: -80°C for 1 year

溶解度: DMSO : 55.31 mg/mL(50 mM)


关键字: SJF 8240 | SJF8240 | SJF-8240

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注：该产品未在中华人民共和国食品药品监督管理部门申请医疗器械注册和备案，不可用于临床诊断或治疗等相关用途