para-amino-Blebbistatin T36400
品牌 | 厂商性质 | 产地 | 货期 |
---|---|---|---|
TargetMol | 生产商 | 美国 | 现货 |
性能特点
生化试剂,可用于动物细胞实验
规格 | CAS号 | 价格 | 操作 |
---|---|---|---|
5 mg | 2097734-03-5 | ¥22,600.00 | 询底价 |
1 mg | 2097734-03-5 | ¥6,280.00 | 询底价 |
500 μg | 2097734-03-5 | ¥3,480.00 | 询底价 |
Product Introduction
Bioactivity
英文名: para-amino-Blebbistatin
描述: para-amino-Blebbistatin is a more water-soluble form of (S)-4'-nitro-blebbistatin , which is a more stable and less phototoxic form of (-)-blebbistatin .1,2,3 (-)-Blebbistatin is a selective cell-permeable inhibitor of non-muscle myosin II ATPases that rapidly and reversibly inhibits Mg-ATPase activity and in vitro motility of non-muscle myosin IIA and IIB for several species (IC50s = 0.5-5 μM), while poorly inhibiting smooth muscle myosin (IC50 = 80 μM).2,3,4 Through these effects, it blocks apoptosis-related bleb formation, directed cell migration, and cytokinesis in vertebrate cells. However, prolonged exposure to blue light (450-490 nm) results in degradation of blebbistatin to an inactive product via cytotoxic intermediates, which may be problematic for its use in fluorescent live cell imaging applications.5,6 The addition of a 4'-amino group increases its water solubility, decreases the inherent fluorescence, stabilizes the molecule to circumvent its degradation by prolonged blue light exposure, and decreases its phototoxicity while retaining the in vitro and in vivo activity of blebbistatin.7 para-amino-Blebbistatin has the same stereochemistry as the active (-)-blebbistatin enantiomer.
存储条件: Powder: -20°C for 3 years | In solvent: -80°C for 1 year
溶解度: DMF:PBS (pH 7.2) (1:1) : 0.5 mg/mL
DMF : 20 mg/mL
DMSO : 12.5 mg/mL
关键字: paraaminoBlebbistatin | para amino Blebbistatin | para-amino-Blebbistatin
para-amino-Blebbistatin T36400信息由TargetMol中国为您提供,如您想了解更多关于para-amino-Blebbistatin T36400报价、型号、参数等信息,欢迎来电或留言咨询。
注:该产品未在中华人民共和国食品药品监督管理部门申请医疗器械注册和备案,不可用于临床诊断或治疗等相关用途