化合物HTHQ T3647

Product Introduction
Bioactivity


英文名: HTHQ

描述: HTHQ (HTHQ(1-O-Hexyl-2,3,5-trimethylhydroquinone)) 是一种强力的亲脂性酚类抗氧化剂。它通过与活性氧直接反应，清除 ROS，从而形成更稳定的自由基，具有很强的抗氧化活性。

体外活性: HTHQ has an anti-oxidative activity similar to D,L-alpha-tocopherol against lipid peroxidation in linolate micelles initiated by addition of Fe2+. The anti-lipid-peroxidation activity of HTHQ is higher 4.8-fold than that of D,L-alpha-tocopherol against the peroxidation in phosphatidylcholine liposomes initiated by addition of Fe2+. [1] The effects of 0.02% Glu-P-1 or 0.03% MeIQx on the number and area of foci is significantly reduced by 0.125% HTHQ. [2]

体内活性: Treatment with HTHQ potently inhibits PhIP-induced mammary carcinogenesis in female rats. Compared with DMN-induced hepatic fibrosis animals in the liver tissue, HTHQ reduced mRNA level of PDGF (Platelet-derived growth factor), α-SMA (α-smooth muscle actin) and TGF-β (transforming growth factor-β). In this study, we showed that HTHQ improves against DMN-induced liver fibrosis in male SD rats.

存储条件: Powder: -20°C for 3 years | In solvent: -80°C for 1 year

溶解度: DMSO : 43 mg/mL(181.9 mM)


关键字: BTT 105 | BTT105 | HTHQ | inhibit | BTT-105 | HX-1171 | Reactive Oxygen Species | Inhibitor | HX1171

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相关库: Anti-Aging Compound Library | Antioxidant Compound Library | Drug Repurposing Compound Library | Bioactive Lipid Compound Library | Anti-Cancer Compound Library | Mitochondria-Targeted Compound Library | Anti-Cancer Drug Library | Anti-Ovarian Cancer Compound Library | Anti-Cancer Clinical Compound Library | Cuproptosis Compound Library

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注：该产品未在中华人民共和国食品药品监督管理部门申请医疗器械注册和备案，不可用于临床诊断或治疗等相关用途