(±)5(6)-DiHET lactone T36556

Product Introduction
Bioactivity


英文名: (±)5(6)-DiHET lactone

描述: 5,6-DiHET lactone is a lactonized form of 5,6-EET and 5,6-DiHET. In solution, 5(6)-EET degrades into 5(6)-DiHET and 5(6)-δ-lactone, which can be converted to 5(6)-DiHET and quantified by GC-MS. 5,6-DiHET potently induces vasodilation of isolated canine coronary arterioles, with 41 and 100% inhibition occurring at 0.01 and 100 pM, respectively. It also induces vasodilation in isolated human microvessels and increases intracellular calcium levels in a dose-dependent manner, an effect that can be blocked by the nitric oxide scavenger L-NAME .

存储条件: Powder: -20°C for 3 years | In solvent: -80°C for 1 year

溶解度: DMF : >50 mg/mL (per Rao Maddipati)
Ethanol : >50 mg/mL (per Rao Maddipati)
PBS (pH 7.2) : >1 mg/mL (from 13(S)-HODE)
DMSO : >50 mg/mL (per Rao Maddipati)


关键字: 5(6)-DiHET lactone | (±)5(6)DiHET lactone | (±)5(6) DiHET lactone

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注：该产品未在中华人民共和国食品药品监督管理部门申请医疗器械注册和备案，不可用于临床诊断或治疗等相关用途