Rp-cAMPS sodium salt T36679
品牌 | 厂商性质 | 产地 | 货期 |
---|---|---|---|
TargetMol | 生产商 | 美国 | 现货 |
性能特点
生化试剂,可用于动物细胞实验
规格 | CAS号 | 价格 | 操作 |
---|---|---|---|
100 mg | 142439-94-9 | ¥17,500.00 | 询底价 |
25 mg | 142439-94-9 | ¥10,600.00 | 询底价 |
50 mg | 142439-94-9 | ¥13,800.00 | 询底价 |
Product Introduction
Bioactivity
英文名: Rp-cAMPS sodium salt
描述: Rp-cAMPS sodium salt, a cAMP analog, is a potent, competitive cAMP-induced activation of cAMP-dependent PKA I and II (Kis of 12.5 μM and 4.5 μM, respectively) antagonist. Rp-cAMPS sodium salt is resistant to hydrolysis by phosphodiesterases[1][2][3][4][5][6].
体外活性: A membrane-permeable competitive cAMP antagonist (Rp-cAMPS) that blocks PKA activation by binding to the regulatory subunits without dissociating the kinase holoenzyme also inhibits synaptic plasticity but has no effect on normal synaptic transmission[2].
体内活性: Rp-cAMPS (10 μM, 15 min) decreases the monosynaptic EPSCs evoked at the PB-CeLC and BLA-CeLC synapses in slices from arthritic rats but not in control neurons from normal animals. The inhibitory effect of Rp-cAMPS is significant compared to predrug (ACSF) control values obtained in the same neurons[2].
存储条件: Powder: -20°C for 3 years | In solvent: -80°C for 1 year
关键字: Rp cAMPS sodium salt | RpcAMPS sodium salt | Rp-cAMPS sodium
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