Sorafenib N-oxide T36681
品牌 | 厂商性质 | 产地 | 货期 |
---|---|---|---|
TargetMol | 生产商 | 美国 | 现货 |
性能特点
生化试剂,可用于动物细胞实验
规格 | CAS号 | 价格 | 操作 |
---|---|---|---|
1 mg | 583840-03-3 | ¥2,110.00 | 询底价 |
5 mg | 583840-03-3 | ¥6,860.00 | 询底价 |
Product Introduction
Bioactivity
英文名: Sorafenib N-oxide
描述: Sorafenib N-oxide is an active metabolite of sorafenib , an inhibitor of Raf-1, B-RAF, and receptor tyrosine kinases. Sorafenib N-oxide inhibits FLT3 that contains the internal tandem duplication mutation (FLT3-ITD; Kd = 70 nM) and inhibits proliferation of MV4-11 acute myeloid leukemia (AML) cells expressing FLT3-ITD (IC50 = 25.8 nM). It is selective for AML cell lines containing FLT3-ITD over lines containing wild-type FLT3 (IC50s = 3.9-13.3 μM). Sorafenib N-oxide is also a linear-mixed inhibitor of the cytochrome P450 (CYP) isoform CYP3A4 (Ki = 15 μM in human liver microsomes).
存储条件: Powder: -20°C for 3 years | In solvent: -80°C for 1 year
溶解度: Methanol : Very slightly soluble
DMSO : Soluble
关键字: Sorafenib Noxide | Sorafenib N oxide | Sorafenib N-oxide
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注:该产品未在中华人民共和国食品药品监督管理部门申请医疗器械注册和备案,不可用于临床诊断或治疗等相关用途