CDK5 inhibitor 20-223 T36742
品牌 | 厂商性质 | 产地 | 货期 |
---|---|---|---|
TargetMol | 生产商 | 美国 | 现货 |
性能特点
生化试剂,可用于动物细胞实验
规格 | CAS号 | 价格 | 操作 |
---|---|---|---|
25 mg | 865317-30-2 | ¥5,970.00 | 询底价 |
2 mg | 865317-30-2 | ¥987.00 | 询底价 |
50 mg | 865317-30-2 | ¥7,920.00 | 询底价 |
100 mg | 865317-30-2 | ¥12,200.00 | 询底价 |
5 mg | 865317-30-2 | ¥1,740.00 | 询底价 |
1 mL | 865317-30-2 | ¥1,830.00 | 询底价 |
Product Introduction
Bioactivity
英文名: CDK5 inhibitor 20-223
描述: CDK5 inhibitor 20-223, a potent inhibitor of CDK2 and CDK5, demonstrates IC50 values of 6.0 nM and 8.8 nM, respectively. It serves as an effective agent against colorectal cancer (CRC)[1].
体外活性: CDK5 inhibitor 20-223 (10 nM-10 μM; 72 hours) potently inhibits cell growth in a panel of colorectal cancer (CRC) cell lines[1].CDK5 inhibitor 20-223 (0.3125-20 μM; 6 hours) induces a dose-dependent decrease in pRB (S807/811) and pFAK (S732) levels in each of the three CRC cell lines[1]. Cell Viability Assay[1] Cell Line: CRC cell lines SW620, DLD1, HT29, HCT116, FET, CBS, and GEO cells
体内活性: CDK5 inhibitor 20-223 (8mg/kg; subcutaneously; for 14 injections) shows anti-tumor activity in human CRC xenograft tumors in nude mice[1]. Animal Model: Athymic nude mice[1]
存储条件: Powder: -20°C for 3 years | In solvent: -80°C for 1 year
关键字: CDK5 inhibitor 20223 | CDK5 inhibitor 20 223 | CDK-5 inhibitor 20-223
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注:该产品未在中华人民共和国食品药品监督管理部门申请医疗器械注册和备案,不可用于临床诊断或治疗等相关用途