S-三苯甲基-L-半胱氨酸 T36816

Product Introduction
Bioactivity


英文名: S-trityl-L-Cysteine

描述: S-Trityl-L-cysteine 是别构驱动蛋白Eg5的选择性抑制剂。rityl-L-cysteine 抑制基础 ATPase 活性的IC50为 1 μM，抑制微管激活的 ATPase 活性的IC50为 140 nM。S-Trityl-L-cysteine 显示出抗肿瘤活性。

体外活性: In vitro, S-trityl-L-Cysteine targets the catalytic domain of Eg5 and inhibits Eg5 basal and microtubule-activated ATPase activity as well as mant-ADP release. S-trityl-L-Cysteine is a tight binding inhibitor (estimation of K(i,app) <150 nm at 300 mm NaCl and 600 nm at 25 mm KCl). S-trityl-L-Cysteine binds more tightly than monastrol because it has both an approximately 8-fold faster association rate and approximately 4-fold slower release rate (6.1/microM/s and 3.6/s for S-trityl-L-Cysteine versus 0.78 /microM/s and 15/s for monastrol). S-trityl-L-Cysteine inhibits Eg5-driven microtubule sliding velocity in a reversible fashion with an IC50 of 500 nm[2].

存储条件: keep away from moisturePowder: -20°C for 3 years | In solvent: -80°C for 1 year

溶解度: DMSO : Slightly soluble
Methanol : 1 mg/mL


关键字: S-Tritylcysteine | Kinesin | StritylLCysteine | Apoptosis | 328542 | inhibit | cell cycle arrest | Inhibitor | NSC 83265 | antitumor activities | NSC-83265 | ATPase activity | kinesin Eg5 | S-trityl-L-Cysteine | NSC83265 | S trityl L Cysteine

相关产品: Ispinesib | Empesertib | GW406108X(Z/E) | SB-743921 hydrochloride | Eg5 Inhibitor V, trans-24 | PVZB1194 | Dimethylenastron | CFI-402257 | AZD-4877 | PF-2771

相关库: Anti-Cancer Compound Library | Microtubule-Targeted Compound Library | Bioactive Compounds Library Max | Peptide Compound Library | Inhibitor Library | Cytoskeletal Signaling Pathway Compound Library | Anti-Cancer Active Compound Library | Bioactive Compound Library

S-三苯甲基-L-半胱氨酸 T36816信息由TargetMol中国为您提供，如您想了解更多关于S-三苯甲基-L-半胱氨酸 T36816报价、型号、参数等信息，欢迎来电或留言咨询。

注：该产品未在中华人民共和国食品药品监督管理部门申请医疗器械注册和备案，不可用于临床诊断或治疗等相关用途