PK7242 (maleate) T36934
品牌 | 厂商性质 | 产地 | 货期 |
---|---|---|---|
TargetMol | 生产商 | 美国 | 现货 |
性能特点
生化试剂,可用于动物细胞实验
规格 | 价格 | 操作 |
---|---|---|
5 mg | ¥7,210.00 | 询底价 |
500 μg | ¥997.00 | 询底价 |
1 mg | ¥1,870.00 | 询底价 |
Product Introduction
Bioactivity
英文名: PK7242 (maleate)
描述: The protein p53, often called the 'guardian of the genome,' is a transcription factor that is activated in response to cellular stress (low oxygen levels, heat shock, DNA damage, etc.) and acts to prevent further proliferation of the stressed cell by promoting cell cycle arrest or apoptosis. Its role as a tumor suppressor is evident by the observation that approximately 50% of human tumors have mutated or non-functional p53. PK7242 is an inducer of reactivation of mutant p53 in cancer cells. In cancer cells carrying the Y220C mutant, PK7242 binds to the p53-Y220C core domain and induces growth inhibition, cell-cycle arrest, and apoptosis.
存储条件: Powder: -20°C for 3 years | In solvent: -80°C for 1 year
溶解度: DMF : 30 mg/mL
DMSO : 16 mg/mL
Ethanol : 3 mg/mL
PBS (pH 7.2) : 2 mg/mL
关键字: PK-7242 (maleate) | PK 7242 | PK-7242 | PK7242
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注:该产品未在中华人民共和国食品药品监督管理部门申请医疗器械注册和备案,不可用于临床诊断或治疗等相关用途