7β,27-dihydroxy Cholesterol T36998

Product Introduction
Bioactivity


英文名: 7β,27-dihydroxy Cholesterol

描述: 7β,27-dihydroxy Cholesterol is an oxysterol and agonist of retinoic acid receptor-related orphan receptor γ (RORγ) and RORγt. [1] It activates RORγ- or RORγt-dependent signaling with EC50 values of 691 and 1,045 nM, respectively, in reporter assays using HEK293T cells expressing the recombinant human receptors. 7β,27-dihydroxy Cholesterol is selective for RORγ and RORγt over a panel of eight additional nuclear receptors at 30 µM. It increases IL-17A production in Th17-polarized isolated human na ve CD4+ T cells when used at a concentration of 300 nM. 7β,27-dihydroxy Cholesterol (60 mg/kg) increases IL-17A production in isolated mouse γδ T cells stimulated with 12-myristate 13-acetate and ionomycin .

存储条件: Powder: -20°C for 3 years | In solvent: -80°C for 1 year

溶解度: Ethanol:PBS (pH 7.2) (1:2) : 0.30 mg/mL
Ethanol : 20 mg/mL
DMF : 2 mg/mL


关键字: 7beta,27-DHC | 7β,27dihydroxy Cholesterol | 7beta,27-dihydroxy Cholesterol | 7b,27-DHC | 7b,27-dihydroxy Cholesterol | 7β,27 dihydroxy Cholesterol

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