化合物SCH900776 S-isomer T3700

Product Introduction
Bioactivity


英文名: SCH900776 (S-isomer)

描述: SCH900776 S-isomer (MK-8776 S-isomer) 是SCH900776的S 型同分异构体。

体外活性: SCH 900776 does not significantly inhibit HLMs CYP450 isoforms 1A2, 2C9, 2C19, 2D6, and 3A4. SCH 900776 induces a dose-dependent loss of DNA replication capability 24 hours after hydroxyurea exposure. In combination with an antimetabolite, SCH 900776 induces accumulation of γ-H2AX within 2 hours, indicative of replication fork collapse and double-stranded DNA breaks. SCH 900776 also dose-dependently suppresses accumulation of the Chk1 pS296 autophosphorylation.

体内活性: After pretreatment 30 minutes with gemcitabine, SCH 900776 (4 mg/kg) is sufficient to induce the γ-H2AX biomarker while 8 mg/kg leads to enhanced tumor pharmacodynamic and regression responses relative to gemcitabine or SCH 900776 alone. SCH 900776 (16/32 mg/kg) dose-dependently induces improvements in tumor response. Doses of SCH 900776 associate with robust biomarker activation and improved tumor response are not associated with enhanced toxicity of gemcitabine on hematological parameters in BALB/c mice.

存储条件: Powder: -20°C for 3 years | In solvent: -80°C for 1 year

溶解度: DMSO : 100 mg/mL (265.78 mM)


关键字: SCH900776 (S-isomer) | SCH900776 (S isomer) | inhibit | SCH-900776 | SCH-900776 (S-isomer) | SCH 900776 | SCH900776 (Sisomer) | SCH900776 | S-isomer | Inhibitor

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相关库: Drug Repurposing Compound Library | Anti-Breast Cancer Compound Library | Anti-Cancer Drug Library | Inhibitor Library | Anti-Cancer Clinical Compound Library | Kinase Inhibitor Library | Anti-Cancer Active Compound Library | Hematonosis Compound Library | NO PAINS Compound Library | Bioactive Compound Library

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