MPS1/TTK Inhibitor T37050
品牌 | 厂商性质 | 产地 | 货期 |
---|---|---|---|
TargetMol | 生产商 | 美国 | 现货 |
性能特点
生化试剂,可用于动物细胞实验
规格 | CAS号 | 价格 | 操作 |
---|---|---|---|
100 mg | 1202055-39-7 | ¥17,500.00 | 询底价 |
25 mg | 1202055-39-7 | ¥10,600.00 | 询底价 |
50 mg | 1202055-39-7 | ¥13,800.00 | 询底价 |
Product Introduction
Bioactivity
英文名: MPS1/TTK Inhibitor
描述: MPS1/TTK inhibitor is an inhibitor of monopolar spindle 1 (MPS1/TTK; IC50 = 5.8 nM), a kinase involved in mitotic spindle checkpoint signaling that is overexpressed in certain cancerous tumors. It inhibits MPS1 phosphorylation of kinetochore scaffold 1 (KNL1) and increases the rate of mitosis and the number of cells entering anaphase within 15 minutes, indicating MPS1 checkpoint inhibition, when used at a concentration of 100 nM. MPS1/TTK inhibitor (50 and 100 nM) increases the number of missegregated chromosomes, with an increased number of errors at 100 nM compared with 50 nM. It also inhibits colony formation of DLD1, HCT116, and U2OS cells (IC50s = 24.6, 20.1, and 20.6 nM, respectively).
存储条件: Powder: -20°C for 3 years | In solvent: -80°C for 1 year
溶解度: H2O : Slightly soluble
关键字: MPS-1/TTK Inhibitor
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注:该产品未在中华人民共和国食品药品监督管理部门申请医疗器械注册和备案,不可用于临床诊断或治疗等相关用途