Chk1-IN-5 T37098
品牌 | 厂商性质 | 产地 | 货期 |
---|---|---|---|
TargetMol | 生产商 | 美国 | 现货 |
性能特点
生化试剂,可用于动物细胞实验
规格 | CAS号 | 价格 | 操作 |
---|---|---|---|
25 mg | 2120398-39-0 | ¥16,100.00 | 询底价 |
50 mg | 2120398-39-0 | ¥21,300.00 | 询底价 |
100 mg | 2120398-39-0 | ¥27,500.00 | 询底价 |
Product Introduction
Bioactivity
英文名: Chk1-IN-5
描述: Chk1-IN-5 is a highly effective inhibitor of checkpoint kinase 1 (Chk1), which hinders the phosphorylation of Chk1 and effectively suppresses tumor growth in a colon cancer xenograft model[1].
体外活性: Chk1-IN-5 (compound 3; 0.4, 1.2, 3.7, 11.1, 33.3, 100 nM) inhibits Chk1 phosphorylation in the HT-29 colon cells[1].
体内活性: Chk1-IN-5 (compound 3; 40 mg/kg; IV; twice a week for 21 days) inhibits tumor growth in Baib/c nude mice with HT-29 colon cancer cells[1].Chk1-IN-5 (10 mg/kg; via tail vein intravenous injection) displays a longer half-life (T1/2=3.8 hours) and higher exposure (CL=2.3 L/hr?kg; Vss=6.4 L/kg; AUC=4531 ng/ml?h)[1]. Animal Model: Baib/c nude mice with HT-29 colon cancer cells[1]
存储条件: Powder: -20°C for 3 years | In solvent: -80°C for 1 year
关键字: Chk-1-IN-5 | Chk1IN5 | Chk1 IN 5
Chk1-IN-5 T37098信息由TargetMol中国为您提供,如您想了解更多关于Chk1-IN-5 T37098报价、型号、参数等信息,欢迎来电或留言咨询。
注:该产品未在中华人民共和国食品药品监督管理部门申请医疗器械注册和备案,不可用于临床诊断或治疗等相关用途