阿西鲁司特 T3715

Product Introduction
Bioactivity


英文名: Acebilustat

描述: Acebilustat (CTX-4430) 是一种具有口服活性的白三烯 A4 水解酶抑制剂，可用于炎症研究。

激酶实验: Rolapitant is made at a stock concentration of 1 mM in 100% DMSO. For most receptor binding studies, the stock solution is diluted with the final concentrations ranged from 0.1 to 3 μM. Radioligand concentrations for competition binding studies ranged from 0.5 to 1 nM. For species comparison studies, 150 pM [125I]-BHSP is incubated with varying concentrations of protein (10-50 μg) prepared from gerbil, rabbit and monkey striata, and from cells expressing cloned rat, mouse and guinea pig NK receptors[1].

体外活性: Acebilustat is a leukotriene A4 hydrolase inhibitor, which is safe and well tolerated in phase 1 trial[1]. Acebilustat is an antiinflammatory drug in development for the treatment of CF and other diseases. It is a potent inhibitor of the enzyme leukotriene A4 hydrolase (LTA4H), which catalyzes the rate-limiting step in the formation of leukotriene B4 (LTB4), a potent chemoattractant and activator of inflammatory immune cells including neutrophils[2].

存储条件: Powder: -20°C for 3 years | In solvent: -80°C for 1 year

溶解度: DMSO : 10 mM
Methanol : 32 mg/mL


关键字: CTX 4430 | Aminopeptidase | Inhibitor | inhibit | CTX4430 | Acebilustat

相关产品: SC-22716 | Firibastat | Puromycin aminonucleoside | Bestatin hydrochloride | Bestatin | Tosedostat | Methyl arachidate | L(+)-Leucinol | α-Cyclopentyl-4-(2-quinolinylmethoxy)benzeneacetic acid | ARM1

相关库: Drug Repurposing Compound Library | ReFRAME Related Library | Clinical Compound Library | Bioactive Compounds Library Max | Inhibitor Library | Metabolism Compound Library | Orally Active Compound Library | Target-Focused Phenotypic Screening Library | Nonsteroidal Anti-Inflammatory Compound Library | Bioactive Compound Library

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注：该产品未在中华人民共和国食品药品监督管理部门申请医疗器械注册和备案，不可用于临床诊断或治疗等相关用途