D-erythro/L-threo Lysosphingomyelin (d18:1) T37187

Product Introduction
Bioactivity


英文名: D-erythro/L-threo Lysosphingomyelin (d18:1)

描述: Lysosphingomyelin is an endogenous bioactive sphingolipid and a constituent of lipoproteins.1,2It is produced by the removal of the acyl group from sphingomyelin by a deacylase and acts as a precursor in the biosynthesis of sphingosine-1-phosphate . D-erythroLysosphingomyelin is an agonist of the S1P receptors S1P1, S1P2, and S1P3(EC50s = 167.7, 368.1, and 482.6 nM, respectively, for the human receptors).3It is also an agonist of the orphan receptor ovarian cancer G protein-coupled receptor 1 (ORG1) that induces calcium accumulation in cells overexpressing OGR1 (EC50= ~35 nM).4Levels of D-erythrolysosphingomyelin are increased in skin isolated from patients with atopic dermatitis, as well as postmortem brain from patients with Niemann-Pick disease type A, but not type B.2,5L-threolysosphingomyelin is also an S1P1-3agonist (EC50s = 19.3, 131.8, and 313.3 nM, respectively).3This product is a mixture of D-erythroand L-threolysosphingomyelin.

存储条件: Powder: -20°C for 3 years | In solvent: -80°C for 1 year

关键字: Derythro/Lthreo Lysosphingomyelin (d18:1) | D-erythro/L-threo Lysosphingomyelin (d-18:1) | d18:1 | D-erythro/L-threo Lysosphingomyelin | D erythro/L threo Lysosphingomyelin (d18:1)

D-erythro/L-threo Lysosphingomyelin (d18:1) T37187信息由TargetMol中国为您提供，如您想了解更多关于D-erythro/L-threo Lysosphingomyelin (d18:1) T37187报价、型号、参数等信息，欢迎来电或留言咨询。

注：该产品未在中华人民共和国食品药品监督管理部门申请医疗器械注册和备案，不可用于临床诊断或治疗等相关用途