F13714 fumarate T37622

Product Introduction
Bioactivity


英文名: F13714 fumarate

描述: F13714 fumarate, a selective biased agonist of the 5-HT1A receptor, exhibits antidepressant-like effects upon single administration in the mouse model of chronic mild stress[1].

体外活性: F13714 targets 5-HT1A autoreceptors[1].

体内活性: In UCMS mice, a single administration of F13714 (4-16 mg/kg) is sufficient to robustly normalize depressive-like behavior in the forced swim test (FST). F13714 rescues cortical and hippocampal deficits in p-ERK1/2 levels but does not influence the p-CREB levels[1]. F13714 decreases the immobility in mice at the doses 2 and 4 mg/kg by 30.3% and 19.5%[1].F13714 (0.5-2 mg/kg) given alone significantly and dose-dependently decreases rectal body temperature in mice during a 2-h measurement[1]. F13714 (2.5 mg/kg) possess antidepressant-and anxiolytic-like properties in na?ve rats[1].

存储条件: Powder: -20°C for 3 years | In solvent: -80°C for 1 year

溶解度: DMSO : 250 mg/mL (463.85 mM)


关键字: F 13714 Fumarate | F-13714 Fumarate | F-13714 fumarate | F13714 Fumarate

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