5(S),12(S)-DiHETE T37649

Product Introduction
Bioactivity


英文名: 5(S),12(S)-DiHETE

描述: 5(S),12(S)-DiHETE is a natural bioactive lipid derived from arachidonic acid . It is synthesized by glycogen-induced rabbit peritoneal polymorphonuclear leukocytes (PMNLs) incubated with AA. 5(S),12(S)-DiHETE can be produced by successive oxygenation of AA by 5-lipoxygenase (5-LO) in platelets and 12-LO in leukocytes. It can also be synthesized from 12(S)-HETE by 5-LO, in the presence of 5-LO activating protein (FLAP), activated with calcium ionophore. 5(S),12(S)-DiHETE is an epimer of leukotriene B4 that is weakly chemotactic for PMNL.

存储条件: Powder: -20°C for 3 years | In solvent: -80°C for 1 year

溶解度: DMSO : >50 mg/mL (per Rao Maddipati)
PBS (pH 7.2) : >1 mg/mL (from 13(S)-HODE)
Ethanol : >50 mg/mL (per Rao Maddipati)
DMF : >50 mg/mL (per Rao Maddipati)


关键字: 5,12DiHETE | 5(S),12(S) DiHETE | 5(S),12(S)DiHETE

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注：该产品未在中华人民共和国食品药品监督管理部门申请医疗器械注册和备案，不可用于临床诊断或治疗等相关用途