6',7'-Epoxybergamottin T37810
品牌 | 厂商性质 | 产地 | 货期 |
---|---|---|---|
TargetMol | 生产商 | 美国 | 现货 |
性能特点
生化试剂,可用于动物细胞实验
规格 | CAS号 | 价格 | 操作 |
---|---|---|---|
1 mg | 206978-14-5 | ¥788.00 | 询底价 |
10 mg | 206978-14-5 | ¥5,630.00 | 询底价 |
5 mg | 206978-14-5 | ¥2,960.00 | 询底价 |
Product Introduction
Bioactivity
英文名: 6',7'-Epoxybergamottin
描述: 6'7'-Epoxybergamottin is a furanocoumarin found in grapefruit. It is a potent inhibitor of the cytochrome P450 (CYP) isoform CYP3A4 with an IC50 value of 0.30 ppm in a cell-free assay, 0.33 μM in HL7 human liver cells, and 0.22 μM in S9 human intestine cells. It has been studied in the context of drug interactions with grapefruit constituents. It is found in grapefruit juice at concentrations of 0.1-7.4 μM and inhibits the transport of talinolol , a permeability glycoprotein (P-gp/ABCB1) transporter substrate, across Caco-2 cell monolayers (IC50 = 0.7 μM). 6'7'-Epoxybergamottin also has insecticidal properties with a concentration of 5 μg/cm2 leading to 100% mortality of adult olive fruit flies.
存储条件: Powder: -20°C for 3 years | In solvent: -80°C for 1 year
溶解度: DMSO:PBS (pH 7.2) (1:1) : 0.5 mg/mL
Ethanol : 10 mg/mL
DMSO : 30 mg/mL
DMF : 30 mg/mL
关键字: 6',7'Epoxybergamottin | 6',7' Epoxybergamottin | 6',7'-Epoxybergamottin
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注:该产品未在中华人民共和国食品药品监督管理部门申请医疗器械注册和备案,不可用于临床诊断或治疗等相关用途