化合物 N-Desethyl Bimatoprost T37939
品牌 | 厂商性质 | 产地 | 货期 |
---|---|---|---|
TargetMol | 生产商 | 美国 | 现货 |
性能特点
生化试剂,可用于动物细胞实验
规格 | CAS号 | 价格 | 操作 |
---|---|---|---|
1 mg | 155205-89-3 | ¥1,120.00 | 询底价 |
5 mg | 155205-89-3 | ¥4,900.00 | 询底价 |
10 mg | 155205-89-3 | ¥8,690.00 | 询底价 |
Product Introduction
Bioactivity
英文名: N-Desethyl Bimatoprost
描述: N-Desethyl Bimatoprost (17-phenyl trinor PGF2α amide) is an F-series PG analog in which the C-1 carboxyl group has been modified to an unsubstituted amide. PG esters have been shown to have ocular hypotensive activity. PG N-ethyl amides were recently introduced as alternative PG hypotensive prodrugs. Although it has been claimed that PG amides are not converted to the free acids in vivo, studies have shown that bovine and human corneal tissue converts the amides of various PGs to the free acids with a conversion efficiency of about 10-20% relative to the hydrolysis of isopropyl esters. 17-phenyl trinor PGF2α amide would be expected to show the typical intraocular effects of latanoprost, but with the much slower hydrolysis pharmacokinetics of the PG N-amides.
存储条件: Powder: -20°C for 3 years | In solvent: -80°C for 1 year
溶解度: DMSO : 20 mg/mL
DMF : 30 mg/mL
Ethanol : 20 mg/mL
PBS (pH 7.2) : 2 mg/mL
关键字: 17-phenyl trinor Prostaglandin F2a Amide | 17-phenyl trinor Prostaglandin F-2α amide | 17phenyl trinor Prostaglandin F2α amide | N-Desethyl Bimatoprost | 17-phenyl trinor Prostaglandin F2α Amide | 17-phenyl trinor Prostaglandin F2alpha Amide | 17 phenyl trinor Prostaglandin F2α amide
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注:该产品未在中华人民共和国食品药品监督管理部门申请医疗器械注册和备案,不可用于临床诊断或治疗等相关用途