17-phenyl trinor Prostaglandin F2α isopropyl ester T37943
品牌 | 厂商性质 | 产地 | 货期 |
---|---|---|---|
TargetMol | 生产商 | 美国 | 现货 |
性能特点
生化试剂,可用于动物细胞实验
规格 | CAS号 | 价格 | 操作 |
---|---|---|---|
10 mg | 130209-76-6 | ¥9,860.00 | 询底价 |
1 mg | 130209-76-6 | ¥1,270.00 | 询底价 |
5 mg | 130209-76-6 | ¥5,670.00 | 询底价 |
Product Introduction
Bioactivity
英文名: 17-phenyl trinor Prostaglandin F2α isopropyl ester
描述: 17-phenyl trinor PGF2α N-ethyl amide is an F-series prostaglandin analog which has been approved for use as an ocular hypotensive drug, sold under the Allergan trade name Bimatoprost. The N-ethyl amide prostaglandin prodrugs are converted to the active free acid more slowly than the analogous prostaglandin ester prodrugs such as latanoprost. This product is the isopropyl ester of the free acid prostaglandin which corresponds to Bimatoprost. The free acid, 17-phenyl trinor PGF2α, is a potent FP receptor agonist. In human and animal models of glaucoma, FP receptor agonist activity corresponds very closely with intraocular hypotensive activity. The 17-phenyl trinor PGF2α isopropyl ester derivative was examined for IOP-lowering activity during the development of latanoprost. At the dose of 3 μg/eye in the monkey, 17-phenyl trinor PGF2α isopropyl ester was the most potent analog tested in reducing IOP, lowering the IOP 1.3 mm Hg below the level achieved by latanoprost. However, this derivative was also significantly more irritating to the eye than latanoprost.
存储条件: Powder: -20°C for 3 years | In solvent: -80°C for 1 year
溶解度: DMF : 30 mg/mL
DMSO : 30 mg/mL
Ethanol : 50 mg/mL
Ethanol:PBS (pH 7.2) (1:1) : 1 mg/mL
关键字: 17phenyl trinor Prostaglandin F2α isopropyl ester | 17 phenyl trinor Prostaglandin F2α isopropyl ester | 17-phenyl trinor Prostaglandin F-2α isopropyl ester
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