化合物(S)-Coriolic acid T37974

Product Introduction
Bioactivity


英文名: (S)-Coriolic acid

描述: (S)-Coriolic acid (13(S)-HODE) 是一种重要的细胞内信号剂，是亚油酸与植物和哺乳动物脂氧合酶反应生成的，在各种生物系统中参与细胞增殖和分化。(S)-Coriolic acid 在 1 μM 左右时，它能抑制肿瘤细胞与血管内皮的粘附，能下调 IRGpIIb/IIIa 受体的表达。(S)-Coriolic acid 是15-脂氧合酶 (15-LOX) 代谢产物，常作为内源性配体激活 PPARγ。(S)-Coriolic acid 诱导线粒体功能障碍 和气道上皮损伤。

体外活性: (S)-Coriolic acid (30 nM; 6 h; E-FABP-/- keratinocytes) induces K1 expression through NF-κB activation. (S)-Coriolic acid also increases the phosphorylation of Ikkinase-bat tyrosine 199, which promotes IκBα phosphorylation and subsequent NF-kB activation. (S)-Coriolic acid increases the phosphorylation of IκBαat serine 32, which induces IκB degradation and thereby activates NF-κB.[3]

体内活性: (S)-Coriolic acid (0-0.6 mg; Intranasal; once a day for 3 consecutive days; mouse) induces pronounced airway dysfunction, airway neutrophilia, mitochondrial dysfunction, and epithelial injury.[2]

存储条件: Powder: -20°C for 3 years | In solvent: -80°C for 1 year

溶解度: Ethanol : >50 mg/mL (per Rao Maddipati)
DMSO : 55 mg/mL (185.54 mM)
PBS (pH 7.2) : 1 mg/mL
DMF : >50 mg/mL (per Rao Maddipati)


关键字: 13HODE | Coriolic acid

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